青光眼不同严重程度阶段的 RETeval 便携式视网膜电图参数。
RETeval Portable Electroretinogram Parameters in Different Severity Stages of Glaucoma.
机构信息
Department of Ophthalmology, Kyorin University School of Medicine.
Department of Ophthalmology, Semmelweis University, Budapest, Hungary.
出版信息
J Glaucoma. 2020 Jul;29(7):572-580. doi: 10.1097/IJG.0000000000001509.
UNLABELLED
PRéCIS:: Four parameters of the noninvasive, portable RETeval electroretinogram (ERG) system were found to correlate with visual field mean deviation and optical coherence tomography (OCT) thickness parameters, and may therefore be suitable for glaucoma detection.
PURPOSE
To investigate the RETeval full-field ERG parameters for accuracy of separating glaucoma and normal eyes, and correlation with glaucoma severity.
PATIENTS AND METHODS
Sixty-two eyes of 62 primary open-angle glaucoma patients [visual field mean deviation (MD) range: -0.44 to -31.15 dB] and 39 eyes of 39 healthy controls underwent one RETeval test (photopic negative response protocol), OCT imaging, and Humphrey 30-2 visual field testing. The glaucoma patients were divided into early (MD≥-6dB, n=33) and moderate-to-advanced (MD<-6 dB, n=29) groups.
RESULTS
Significant correlations were found between the best-performing 4 RETeval ERG parameters and the glaucoma severity measures (MD and OCT thickness parameters) for all eyes, all glaucoma eyes and the moderate-to-advanced glaucoma eyes [photopic negative response amplitude at 72 ms (PhNR 72) and MD: r=-0.333, -0.414, and -0.485, respectively, P≤0.008; PhNR 72 and average circumpapillary retinal nerve fiber layer thickness; r=-0.429, -0.450, and -0.542, respectively, P≤0.002]. Except for P-ratio, there was no significant difference between the area under the receiver-operating characteristic (AUROC) values of the OCT thickness parameters (range: 0.927 to 0.938) and the 4 best-performing RETeval ERG parameters (range: 0.839 to 0.905) in the early glaucoma versus control separation. For differentiating the control and the moderate-to-advanced glaucoma eyes, the AUROC values of the 4 best-performing RETeval ERG parameters ranged between 0.924 and 0.958, and no significant difference was found between them and those of the OCT parameters.
CONCLUSIONS
The noninvasive, portable RETeval full-field ERG device may be useful to detect glaucoma in moderate-to-advanced stages.
目的
研究 RETeval 全视野视网膜电图（ERG）参数在青光眼检测中的准确性和与疾病严重程度的相关性。
方法
62 只原发性开角型青光眼患者（视野平均偏差（MD）范围：-0.44 至-31.15 dB）和 39 只健康对照者接受了一次 RETeval 测试（明视负反应方案）、OCT 成像和 Humphrey 30-2 视野测试。将青光眼患者分为早期（MD≥-6dB，n=33）和中晚期（MD<-6 dB，n=29）两组。
结果
所有眼、所有青光眼眼和中晚期青光眼眼中，最佳的 4 个 RETeval ERG 参数与青光眼严重程度测量值（MD 和 OCT 厚度参数）之间存在显著相关性[72ms 时的明视负反应波振幅（PhNR 72）和 MD：r=-0.333、-0.414 和-0.485，P 值均≤0.008；PhNR 72 和平均环周视网膜神经纤维层厚度：r=-0.429、-0.450 和-0.542，P 值均≤0.002]。除 P 比外，OCT 厚度参数（范围：0.927 至 0.938）和最佳的 4 个 RETeval ERG 参数（范围：0.839 至 0.905）在早期青光眼与对照组的区分中，其受试者工作特征（ROC）曲线下面积（AUC）值之间无显著差异。对于中晚期青光眼与对照组的区分，最佳的 4 个 RETeval ERG 参数的 AUC 值在 0.924 至 0.958 之间，与 OCT 参数之间无显著差异。
结论
非侵入性、便携式 RETeval 全视野 ERG 设备可能有助于检测中晚期青光眼。
Zotero 插件