Deng Qiao, Tang Lu, Wu Xi, Wu Tao, He Shuai, Li Lei, Cheng Wei, Diao Yi-Ke, Diao Kai-Yue, Yue Wen-Jun, Chen Yu-Cheng, Sun Jia-Yu
Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2022 May;53(3):497-503. doi: 10.12182/20220560506.
To explore the feasibility of single-breath-hold compressed sensing real-time cine imaging (CS-cine) in the assessment of ventricular function and left ventricular (LV) strain.
A total of 70 subjects were enrolled prospectively, and all subjects underwent cardiac magnetic resonance imaging (cardiac MRI) using both the standard steady-state free procession cine (sta-cine) acquisition and a prototype CS-cine sequence. For both CS-cine and sta-cine imaging, continuous short-axis cine images were acquired from the base to the apex to cover the entire left ventricle, and long-axis cine images including two-, three-, and four-chamber views were also acquired. The scanning range, number of slices, slice thickness and intervals were kept identical for the two cine images of the same participant. Subjective evaluation of the image quality was performed on all cine images. For both sequences, the conventional function parameters of the left and the right ventricles and LV strain values were assessed with post-processing software analysis. The cine image quality, conventional ventricular function parameters, and LV strain values were compared between the two cine groups and the differences were examined. Inter- and intraobserver agreements for CS-cine images were measured using intraclass correlation coefficient ( ). Bland-Altman analysis was performed to assess reproducibility between the two cine methods.
The median scanning time of CS-cine was 21 s versus 272 s for sta-cine ( <0.001). The median image quality scores of two groups were significantly different, 4 points for sta-cine and 2 points for CS-cine ( <0.001). Bi-ventricular end-diastolic volumes (EDV), stroke volume (SV) and ejection fraction (EF) were significantly smaller in CS-cine ( <0.001). Nevertheless, no significant differences between the two groups in bi-ventricular ESV or LV mass were observed ( >0.05). LV strain parameters, including the peak radial strain, peak circumferential strain and peak longitudinal strain derived from LV mid-ventricular slice, were significantly different in the two sequences ( <0.001). Moreover, CS-cine-derived functional parameters and strain measurements have a good correlation with those of sta-cine (for RV function parameters, and left ventricular PLS, PCS values, more than 95% points fell within the limits of agreement [ ]; meanwhile, more than 91% points fell within the for other parameters) and inter- and intraobserver agreements were strong ( =0.88 to 0.99) for CS-cine.
CS-cine can well realize the rapid acquisition of cine images for quantitative analysis of cardiac function, and the conventional ventricular function parameters and LV globalized strain values obtained from CS-cine imaging have good reproducibility.
探讨单屏气压缩感知实时电影成像（CS-电影成像）在评估心室功能和左心室（LV）应变方面的可行性。
前瞻性纳入70名受试者，所有受试者均接受心脏磁共振成像（心脏MRI）检查，采用标准稳态自由进动电影（sta-电影成像）采集和原型CS-电影成像序列。对于CS-电影成像和sta-电影成像，均从心底至心尖获取连续的短轴电影图像以覆盖整个左心室，还获取了包括二腔、三腔和四腔视图的长轴电影图像。同一受试者的两种电影图像的扫描范围、层数、层厚和层间距保持相同。对所有电影图像进行图像质量的主观评估。对于这两种序列，使用后处理软件分析评估左、右心室的传统功能参数和LV应变值。比较两组电影图像的电影图像质量、传统心室功能参数和LV应变值，并检验差异。使用组内相关系数（ ）测量CS-电影图像的观察者间和观察者内一致性。进行Bland-Altman分析以评估两种电影成像方法之间的可重复性。
CS-电影成像的中位扫描时间为21秒，而sta-电影成像为272秒（<0.001）。两组的中位图像质量评分有显著差异，sta-电影成像为4分，CS-电影成像为2分（<0.001）。CS-电影成像中的双心室舒张末期容积（EDV）、每搏输出量（SV）和射血分数（EF）显著较小（<0.001）。然而，两组在双心室收缩末期容积或LV质量方面未观察到显著差异（>0.05）。来自LV心室中层切片的LV应变参数，包括峰值径向应变、峰值圆周应变和峰值纵向应变，在两种序列中有显著差异（<0.001）。此外，CS-电影成像得出的功能参数和应变测量值与sta-电影成像的参数有良好的相关性（对于右心室功能参数以及左心室PLS、PCS值，超过95%的点落在一致性界限内[ ]；同时，对于其他参数，超过91%的点落在 内），并且CS-电影成像的观察者间和观察者内一致性很强（ =0.88至0.99）。
CS-电影成像能够很好地实现电影图像的快速采集以用于心脏功能的定量分析，并且从CS-电影成像获得的传统心室功能参数和LV整体应变值具有良好的可重复性。
