Chen Jing, Huang Ze-Yu, Zhou Xue-Dong, Cheng Lei
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2022 May;53(3):523-527. doi: 10.12182/20220560501.
CD47, a transmembrane glycoprotein widely expressed on the cell surface, is one of the important checkpoints through which cells escape innate immune surveillance. The important role of CD47-related signaling pathway and changes in expression level in immune regulation, pathogen infection and anti-tumor immunity has gradually come to be recognized. We reviewed herein the structure and biological characteristics of CD47, the interaction and the downstream signaling of CD47 with integrin, thrombospondin 1, and signal regulatory protein, and the upregulated expression of CD47 induced by the infection of different pathogens and the role of CD47 in different types of immune response to infection. Discussions were made regarding the prospective application of CD47 targeted immunotherapy in pathogenic infection-related cancers, intending to provide guidance for future research.
CD47是一种广泛表达于细胞表面的跨膜糖蛋白，是细胞逃避天然免疫监视的重要检查点之一。CD47相关信号通路在免疫调节、病原体感染和抗肿瘤免疫中的重要作用以及表达水平的变化已逐渐得到认识。本文综述了CD47的结构和生物学特性、CD47与整合素、血小板反应蛋白1和信号调节蛋白的相互作用及下游信号传导，以及不同病原体感染诱导的CD47表达上调及其在不同类型感染免疫反应中的作用。并对CD47靶向免疫疗法在病原体感染相关癌症中的应用前景进行了探讨，旨在为未来研究提供指导。
