Chen Wen-Jie, Wei Jing, Chen Ting-Tao
Queen Marry School, Nanchang University, Nanchang 330000, China.
Institute of Translational Medicine, Nanchang University, Nanchang 330000, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2022 May;53(3):532-537. doi: 10.12182/20220560508.
Surgical resection, radiotherapy, chemotherapy, and immunotherapy are the main therapies for cancers. These cancer therapies all prolong patient survival, but also bring multiple side effects. Gut microbiota participates in almost all the physiological and biochemical processes of the host, playing a key role in human health and diseases. As an exogenous intervention, probiotics can prevent diseases and enhance immunity. Their anti-cancer ability and ameliorative effect have received increasing recognition. Herein, we reported the latest findings on gut microbiota and cancer pathogenesis, focusing on the application of probiotics in reducing the side effects caused by cancer therapies and hoping to provide supportive references for the clinical use of probiotics in cancer treatment.
手术切除、放疗、化疗和免疫疗法是癌症的主要治疗方法。这些癌症治疗方法都能延长患者生存期，但也会带来多种副作用。肠道微生物群几乎参与宿主的所有生理和生化过程，在人类健康和疾病中发挥着关键作用。作为一种外源性干预措施，益生菌可以预防疾病并增强免疫力。它们的抗癌能力和改善作用已得到越来越多的认可。在此，我们报告了肠道微生物群与癌症发病机制的最新研究结果，重点关注益生菌在减轻癌症治疗副作用方面的应用，希望为益生菌在癌症治疗中的临床应用提供支持性参考。
