Department of Animal Sciences, University of Illinois Champaign-Urbana, Champaign-Urbana, Illinois, USA.
Mol Reprod Dev. 2023 Jul;90(7):480-490. doi: 10.1002/mrd.23576. Epub 2022 Jun 1.
Understanding the factors and pathways involved with recruitment, atresia, and selection of follicles in the pig, may provide insight into approaches to limit fertility failures. Antral follicles depend upon FSH to the 2-3 mm stage, become codependent upon LH at 4-5 mm, and rely on LH when >5 mm. Within the follicle, gonadotropin binding, steroids, growth factors, and inhibin interact to determine the fate of the follicle. Continuous recruitment appears likely for follicles, and once >1 mm, they may have a limited period for survival, before selection or atresia. If true, then the number of healthy follicles that can respond to a hormone signal for selection, could vary by size and development stage. Which follicles are selected may depend upon their age, numbers of capillaries, granulosa and thecal cells, and FSH and LH receptors. This might also suggest that factors such as management, nutrition, and stress in prior weeks, could affect different cohorts of follicles to determine which of those from the ovarian population will be selected.
了解猪的卵泡募集、闭锁和选择所涉及的因素和途径，可能有助于找到限制生育力失败的方法。窦前卵泡依赖于 FSH 生长至 2-3mm 阶段，在 4-5mm 时依赖于 LH，而当卵泡大于 5mm 时则依赖于 LH。在卵泡内，促性腺激素结合、类固醇、生长因子和抑制素相互作用，以决定卵泡的命运。卵泡似乎可以持续募集，一旦大于 1mm，它们可能只有有限的生存时间，然后是选择或闭锁。如果这是真的，那么能够对激素信号做出选择反应的健康卵泡的数量，可能会因大小和发育阶段而有所不同。哪些卵泡被选择可能取决于它们的年龄、毛细血管数量、颗粒细胞和膜细胞，以及 FSH 和 LH 受体。这也可能表明，前几周的管理、营养和应激等因素可能会影响不同的卵泡群，以确定从卵巢群体中选择哪些卵泡。
