University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Pediatrics, Cologne, Germany.
University of Cologne, Centre of Prevention and Rehabilitation, Cologne, Germany.
J Musculoskelet Neuronal Interact. 2022 Jun 1;22(2):284-291.
The results of three cases with infantile-onset Pompe disease participating in a rehabilitation program with home-based vibration training will be presented. In this retrospective observational case study, the cases participated in the neuromuscular training program "Auf die Beine", which combines two blocks of intensive, goal directed training with 6 months of home-based whole body vibration (WBV). Assessments by the means of a dual-energy X-ray absorptiometry and grip strength were applied at multiple points throughout the program. Two cases showed an increase in lean mass index of +0.319 kg/m, +0.721 kg/m and bone mineral content of +0.028 kg/m, +0.031 kg/m over one year. Additionally physiotherapeutic therapy goals could be achieved. In the remaining child lean mass index did not change, bone mineral content decreased by -0.03 kg. The neuromuscular rehabilitation program "Auf die Beine" has shown to be safe and effective in two of three cases for muscle and bone mass gain as well as in achievement of physiotherapeutic goals. To summarize, WBV is an innovative therapy in a rehabilitation concept, which might be helpful in Pompe disease, but further studies with larger cohorts are needed.
现将参与基于家庭的振动训练康复计划的三例婴儿期发病庞贝病患者的结果报告如下。在这项回顾性观察性病例研究中，这些病例参加了神经肌肉训练计划“Auf die Beine”，该计划将两阶段密集、有针对性的训练与 6 个月的全身振动（WBV）相结合。在整个计划的多个时间点，通过双能 X 射线吸收法和握力评估来进行评估。有两个病例在一年中分别增加了 0.319 公斤/米和 0.721 公斤/米的瘦体重指数和 0.028 公斤/米和 0.031 公斤/米的骨矿物质含量。此外，还实现了物理治疗的目标。在剩下的孩子中，瘦体重指数没有变化，骨矿物质含量减少了 0.03 公斤。神经肌肉康复计划“Auf die Beine”在两例病例中证明了肌肉和骨量增加以及实现物理治疗目标的安全性和有效性。总之，WBV 是一种创新性的治疗方法，可能对庞贝病有帮助，但需要更大样本量的进一步研究。
