Department of Neurology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, China.
J Musculoskelet Neuronal Interact. 2022 Jun 1;22(2):296-300.
There are few reports of rhabdomyolysis caused by anticoagulants, and it is extremely rare for it to be caused by dabigatran etexilate. An 86-year-old female experienced sudden muscle weakness and pain, a significant increase in Creatine kinase, and renal impairment after oral administration of dabigatran etexilate for 3 weeks. The enhanced thigh MRI showed abnormal signal in multiple thigh muscle groups, indicating that the lesions should be considered inflammatory diseases. In conclusion, the possibility of rhabdomyolysis should be ruled out when muscle weakness and myalgia occur at the beginning of dabigatran etexilate treatment.
鲜有抗凝剂引起横纹肌溶解症的报道，达比加群酯引起者更为罕见。一位 86 岁女性口服达比加群酯 3 周后出现突发肌肉无力和疼痛，肌酸激酶显著升高，伴有肾功能损害。大腿 MRI 增强检查显示多组大腿肌肉群异常信号，提示病变应考虑炎症性疾病。综上，达比加群酯治疗初期出现肌肉无力和肌痛时应排除横纹肌溶解症的可能。
