Katiyar J C, Misra A, Gupta S, Visen P K, Murthy P K, Sen A B
Vet Parasitol. 1987 Feb;23(3-4):193-204. doi: 10.1016/0304-4017(87)90005-7.
The efficacy of a substituted methyl benzimidazole carbamate, methyl 5(6)-[4-N-(2-pyridyl)] piperazino carbamoyl benzimidazole-2-carbamate, was assessed against larval and adult forms of Ancylostoma ceylanicum (hookworm), Nippostrongylus brasiliensis (trichostrongylid), Hymenolepis nana (tapeworm) and Brugia malayi (filariid) in experimentally-infected animals. The compound was found to have high efficacy against the developing stages (L3, L4, L5) of A. ceylanicum in hamsters at a single dose of 12.5 mg kg-1, against larvae of N. brasiliensis at 17.5 mg kg-1 and against cysticercoids of Hymenolepis nana at 100 mg kg-1 daily for 3 days given per os (p.o.) or intraperitoneally (i.p.). All the stages of B. malayi in Mastomys were killed when the compound was given i.p. at a dose of 6.25 mg kg-1 for 5 consecutive days. A dose of 6.25 mg kg-1 eliminated all adult A. ceylanicum from infected hamsters, 100 mg kg-1 resulted in complete removal of Syphacia obvelata adults from 63.6% of infected mice, 25 mg kg-1 X 5 dose eliminated 100% of adult B. malayi from infected Mastomys and a single 50 mg kg-1 dose expelled all H. nana adults from infected rats.
在实验感染的动物中，评估了一种取代的甲基苯并咪唑氨基甲酸酯，即5(6)-[4-N-(2-吡啶基)]哌嗪基氨基甲酰基苯并咪唑-2-氨基甲酸甲酯对锡兰钩口线虫（钩虫）、巴西日圆线虫（毛圆线虫）、微小膜壳绦虫（绦虫）和马来布鲁线虫（丝虫）幼虫和成虫的疗效。发现该化合物对仓鼠体内锡兰钩口线虫的发育阶段（L3、L4、L5）具有高效，单剂量12.5 mg kg-1；对巴西日圆线虫幼虫，17.5 mg kg-1；对微小膜壳绦虫的似囊尾蚴，口服（p.o.）或腹腔注射（i.p.），每日100 mg kg-1，连续3天。当以6.25 mg kg-1的剂量连续5天腹腔注射该化合物时，多乳鼠体内的马来布鲁线虫各阶段均被杀死。6.25 mg kg-1的剂量可清除感染仓鼠体内的所有成年锡兰钩口线虫；100 mg kg-1可使63.6%感染小鼠体内的欧氏管圆线虫成虫完全清除；25 mg kg-1×5剂量可清除感染多乳鼠体内100%的成年马来布鲁线虫；单剂量50 mg kg-1可驱除感染大鼠体内的所有微小膜壳绦虫成虫。
