Srivastava J K, Gupta S, Katiyar J C
Division of Parasitology, Central Drug Research Institute, Lucknow, India.
Trop Med Parasitol. 1988 Dec;39(4):325-7.
The prophylactic action of a substituted methylbenzimidazole carbamate was investigated against experimental nematode infections. The compound at the dose of 100 mg/kg x 1, i.m., protected hamsters against Ancylostoma ceylanicum for about 45 days and at 500 mg/kg x 1 protected rats against Nippostrongylus brasiliensis for 28 days. The uteri of female worms recovered from treated animals were devoid of ova so long the compound had considerable phophylactic action. In case of A. ceylanicum the compound exerted lethal action on L4 stage and in N. brasiliensis, mild action was noticed on L4 which became more pronounced on L5. The reference drugs, mebendazole and thiabendazole, had weaker prophylactic action.
研究了一种取代甲基苯并咪唑氨基甲酸酯对实验性线虫感染的预防作用。该化合物以100mg/kg×1的剂量肌肉注射，可使仓鼠对锡兰钩虫的感染得到约45天的保护；以500mg/kg×1的剂量可使大鼠对巴西日圆线虫的感染得到28天的保护。只要该化合物具有相当的预防作用，从经治疗动物体内回收的雌虫子宫就没有虫卵。对于锡兰钩虫，该化合物对L4期虫体具有致死作用；对于巴西日圆线虫，对L4期虫体有轻微作用，而对L5期虫体的作用更明显。对照药物甲苯达唑和噻苯达唑的预防作用较弱。
