PGY 3Oral and Maxillofacial Surgery Residency ProgramSchool of Dental MedicineMedical Sciences Campus, University of Puerto Rico, Paseo Dr. José Celso Barbosa, San Juan, Puerto Rico, 00921.
PGY 1, Oral and Maxillofacial Surgery Residency Program, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.
Oral Maxillofac Surg. 2023 Sep;27(3):421-426. doi: 10.1007/s10006-022-01080-z. Epub 2022 May 28.
The objective of the present research is to describe the histologic features of the bone regenerated by means of negative pressure (sugosteogenesis) in a group of patients diagnosed with odontogenic keratocyst (OKC) who underwent active decompression and distraction sugosteogenesis (ADDS) at our institution.
The authors designed a retrospective case series study. The population included patients with a histologic diagnosis of odontogenic keratocyst in whom active decompression and distraction sugosteogenesis followed by enucleation was performed. All patients were seen and followed from July 2019 to January 2021. The investigation was approved by the Institutional Review Board, and it observed the Declaration of Helsinki on medical protocol. Variables of this study included age, gender, anatomic location (mandible or maxilla), and histologic characteristics of the bone regenerated by means of negative pressure. Histologic features were defined as being consistent or inconsistent with viable mature bone.
Bone biopsies of 6 patients were considered. In total, 83.33% of patients were males and 16.66% females. One hundred percent of the bone samples subjected to negative pressure showed features of viable mature bone.
In this study, the histological features of the bone subjected to negative pressure demonstrated the normal characteristics of the mature, normal bone.
本研究的目的是描述一组在我院接受积极减压和牵张成骨术（ADDS）治疗的牙源性角化囊肿（OKC）患者中，通过负压再生的骨的组织学特征。
作者设计了一项回顾性病例系列研究。该人群包括经组织学诊断为牙源性角化囊肿的患者，这些患者接受了积极减压和牵张成骨术，然后进行了囊内切除术。所有患者均于 2019 年 7 月至 2021 年 1 月就诊并接受随访。该研究获得了机构审查委员会的批准，并遵守了赫尔辛基医疗协议宣言。本研究的变量包括年龄、性别、解剖部位（下颌骨或上颌骨）和通过负压再生的骨的组织学特征。组织学特征定义为与有活力的成熟骨一致或不一致。
考虑了 6 名患者的骨活检。男性占 83.33%，女性占 16.66%。所有接受负压治疗的骨样本均表现出有活力的成熟骨的特征。
在这项研究中，负压作用下的骨的组织学特征表现出成熟正常骨的正常特征。
