Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.
Sci Rep. 2021 Jun 3;11(1):11673. doi: 10.1038/s41598-021-91104-7.
Osteomyelitis (OM) of the jaw is usually caused by a chronic odontogenic infection. Decompression is the release the intraluminal pressure in the cystic cavity allowing gradual bone growth from the periphery. The aim of this study was to analyze the effectiveness of decompression in an OM jaw model. A 4-mm-diameter defect was made on mandibles of fourteen Sprague-Dawley rats and inoculated with S. aureus (20 μl of 1 × 10 CFU/ml) injection. Two weeks later, four groups were made as non-treatment (C1), only curettage (C2), curettage and decompression (E1), and curettage and decompression with normal saline irrigation (E2). After four weeks, each group was analyzed. Most micro-CT parameters, including bone mineral density [0.87 (± 0.08) g/cm] with bone volume [0.73 (± 0.08) mm] was higher in E2 group than that of C1 group (p = 0.04, p = 0.05, respectively). E2 group in histology showed the highest number of osteocytes than those of control groups, 91.00 (± 9.90) (p = 0.002). OPN were expressed strongly in the E1 ("5": 76-100%) that those of other groups. Decompression drains induced advanced bone healing compared to that of curettage alone. Therefore, it could be recommended to use decompressive drain for enhancing the jaw OM management.
颌骨骨髓炎（OM）通常由慢性牙源性感染引起。减压是释放囊腔腔内的压力，允许骨从周围逐渐生长。本研究旨在分析颌骨 OM 模型中减压的效果。在 14 只 Sprague-Dawley 大鼠的下颌骨上制造一个 4 毫米直径的缺损，并接种金黄色葡萄球菌（20 μl 1×10 CFU/ml）注射。两周后，将四个组分为未治疗（C1）、仅刮除（C2）、刮除和减压（E1）以及刮除和减压加生理盐水冲洗（E2）。四周后，对每组进行分析。大多数微 CT 参数，包括骨矿物质密度[0.87（±0.08）g/cm]和骨体积[0.73（±0.08）mm]在 E2 组均高于 C1 组（p=0.04，p=0.05）。组织学上，E2 组的骨细胞数量最高，为 91.00（±9.90）（p=0.002）。E1 组的 OPN 表达较强（“5”：76-100%），高于其他组。减压引流器可诱导颌骨 OM 管理中比单独刮除术更先进的骨愈合。因此，建议使用减压引流器来增强颌骨 OM 的管理。
