Department of Psychiatry, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, 50-367 Wroclaw, Poland.
J Psychosom Res. 2022 Aug;159:110946. doi: 10.1016/j.jpsychores.2022.110946. Epub 2022 May 14.
The main aim of the study was to investigate the factors related to the biopsychosocial complexity in the group of patients with acromegaly with different disease activity.
A cross-sectional observational study was performed. First, a linguistic adaptation of the INTERMED - self-assessment questionnaire (IMSA) and after that the assessment of the biopsychosocial complexity among patients with acromegaly and the factors which relate to the complexity was made. The following tools were used to assess: biopsychosocial complexity: The INTERMED -self-assessment (IMSA); quality of life: The World Health Organization Quality of Life - BREF (WHOQoL) and Acromegaly Quality of Life questionnaire (AcroQol); mental state: The General Health Questionnaire - 28 (GHQ-28).
The final analysis included 71 patients. According to the principal component analysis the mental state (GHQ-28) and the quality of life (AcroQol) are the most important factors related to the clinical complexity among patients with acromegaly. In the model created by a stepwise regression analysis for the total IMSA score higher growth hormone (GH) concentration, longer illness duration, and better general quality of life were included as the protective factors of the clinical complexity. By contrast, a high score in the severe depression subscale of GHQ-28 was a factor of higher clinical complexity.
The mental state and quality of life are the most important determinants of the clinical complexity in the group of patients with acromegaly whereas the biochemical normalization is of lesser importance.
本研究的主要目的是调查不同疾病活动度的肢端肥大症患者群体中与生物心理社会复杂性相关的因素。
进行了一项横断面观察性研究。首先，对 INTERMED-自我评估问卷（IMSA）进行了语言适应性调整，然后评估了肢端肥大症患者的生物心理社会复杂性及其与复杂性相关的因素。使用以下工具进行评估：生物心理社会复杂性：INTERMED-自我评估（IMSA）；生活质量：世界卫生组织生活质量-简表（WHOQoL）和肢端肥大症生活质量问卷（AcroQol）；精神状态：一般健康问卷-28（GHQ-28）。
最终分析纳入了 71 名患者。根据主成分分析，精神状态（GHQ-28）和生活质量（AcroQol）是肢端肥大症患者临床复杂性相关的最重要因素。在逐步回归分析创建的模型中，较高的生长激素（GH）浓度、较长的疾病持续时间和较好的总体生活质量被纳入临床复杂性的保护因素。相比之下，GHQ-28 中严重抑郁分量表的高分是临床复杂性更高的因素。
在肢端肥大症患者群体中，精神状态和生活质量是临床复杂性的最重要决定因素，而生化正常化的重要性较低。
