Aix-Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
Aix-Marseille Univ, CNRS, IBDM, Institut de Biologie du Développement de Marseille, Marseille, France.
Curr Opin Immunol. 2022 Aug;77:102212. doi: 10.1016/j.coi.2022.102212. Epub 2022 May 26.
With its unique structure and large numbers of immune cells, the skin is one of the body's first lines of defense against attacks from the environment. It is also innervated by a dense meshwork of primary sensory neurons, including nociceptive fibers specializing in the detection and transduction of harmful stimuli that can elicit pain. This tissue is, therefore, a key organ for studies of neuroimmune interactions and their impact on the host response to environmental challenges. Neuroimmune crosstalk in the skin is crucial for the regulation of inflammation, tissue repair, and host defense against pathogens. A better understanding of this regulation would facilitate the identification of new molecular targets for the treatment of skin diseases.
皮肤具有独特的结构和大量的免疫细胞，是人体抵御环境攻击的第一道防线之一。它还由密集的初级感觉神经元网状结构所支配，包括专门用于检测和转导有害刺激的伤害感受纤维，这些刺激会引发疼痛。因此，这种组织是研究神经免疫相互作用及其对宿主对外界环境挑战的反应的关键器官。皮肤中的神经免疫相互作用对于炎症的调节、组织修复以及宿主对病原体的防御至关重要。更好地了解这种调节将有助于确定治疗皮肤病的新分子靶标。
