Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, China; The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, China.
Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, China; The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, China.
Exp Cell Res. 2022 Aug 15;417(2):113227. doi: 10.1016/j.yexcr.2022.113227. Epub 2022 May 27.
Chili pepper and its major active compound capsaicin have long been used not only a daily food additive but also medication worldwide. Like in other human organs and systems, capsaicin has multiple actions in gastrointestinal (GI) physiology and pathology. Numerous studies have revealed that capsaicin acts on GI tract in TRPV1-dependent and -independent manners, mostly depending on its consumption concentrations. In this review, we will focus on the beneficial role of capsaicin in GI tract, a less highlighted aspect, in particular how dietary capsaicin affects GI health, the mechanisms of actions and its preventive/therapeutic potentials to several GI diseases. Dietary capsaicin affects GI tract not only via TRPV1-derpendent and independent manners, but also via acute and chronic effects. Although high dose intake of dietary capsaicin is harmful to human health sometimes, current literatures suggest that appropriate dose intake is likely beneficial to GI health and is preventive/therapeutic to GI disease in most cases as well. With extensive and intensive studies on its GI actions, capsaicin, as a daily consumed food additive, has potential to become a safe drug for the treatment of several GI diseases.
辣椒及其主要活性化合物辣椒素在全球范围内不仅长期用作日常食品添加剂，还用作药物。与其他人类器官和系统一样，辣椒素在胃肠道（GI）生理学和病理学中有多种作用。大量研究表明，辣椒素以 TRPV1 依赖和非依赖的方式作用于胃肠道，这主要取决于其消费浓度。在这篇综述中，我们将重点关注辣椒素在胃肠道中的有益作用，这是一个较少被强调的方面，特别是饮食辣椒素如何影响胃肠道健康、作用机制及其对几种胃肠道疾病的预防/治疗潜力。饮食辣椒素不仅通过 TRPV1 依赖和非依赖的方式影响胃肠道，还通过急性和慢性作用影响胃肠道。尽管高剂量摄入饮食辣椒素有时对人体健康有害，但目前的文献表明，适量摄入可能有益于胃肠道健康，在大多数情况下也可预防/治疗胃肠道疾病。随着对其胃肠道作用的广泛深入研究，作为日常食用的食品添加剂，辣椒素有可能成为治疗几种胃肠道疾病的安全药物。
