Laboratory of Tumor Immunology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China; Department of Nephrology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Laboratory of Tumor Immunology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Clin Immunol. 2022 Aug;241:109046. doi: 10.1016/j.clim.2022.109046. Epub 2022 May 27.
Immunologic dysfunction is one of the most important mechanisms underlying the initiation and development of JORRP. The study aimed to explore whether HPV-specific T-cell response was impaired in JORRP patients. We found JORRP patients had a Th2-biased cytokine profile correlated with disease severity in peripheral system. JORRP patients had an increased memory T cells and a reduced naive T cells in circulation. Upon HPV6/11 antigens stimulation, T cells from JORRP patients exhibited a greater activation profile. Of note, JORRP patients presented with a greater number of IL-10- and IL-4-secreting HPV6/11 antigen responding cells than that of IFN-γ and TNF-α secreting responders. Furthermore, in response to HPV6/11 antigen stimulation, JORRP patients showed a reduced level of cell proliferation, an increased level of apoptosis and higher percentage of the differentiated T cells expressing the replicative senescent cell marker CD57. Impaired HPV-specific T-cell responses could be partly responsible for JORRP development.
免疫功能障碍是 JORRP 发病和发展的最重要机制之一。本研究旨在探讨 JORRP 患者是否存在 HPV 特异性 T 细胞反应受损。我们发现 JORRP 患者在外周系统中存在与疾病严重程度相关的 Th2 偏向细胞因子谱。JORRP 患者在循环中具有更多的记忆 T 细胞和更少的幼稚 T 细胞。在 HPV6/11 抗原刺激下，JORRP 患者的 T 细胞表现出更大的激活谱。值得注意的是，与 IFN-γ 和 TNF-α 分泌应答者相比，JORRP 患者表现出更多的分泌 IL-10 和 IL-4 的 HPV6/11 抗原反应细胞。此外，在 HPV6/11 抗原刺激下，JORRP 患者的细胞增殖水平降低，凋亡水平升高，表达复制性衰老细胞标志物 CD57 的分化 T 细胞比例更高。HPV 特异性 T 细胞反应受损可能是 JORRP 发展的部分原因。
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013-6
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016-5-5
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