Department of Pharmaceutical Engineering, Dankook University, 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungcheongnam-do, Republic of Korea.
Chem Asian J. 2022 Aug 15;17(16):e202200333. doi: 10.1002/asia.202200333. Epub 2022 Jun 15.
Microneedle (MN) is a minimally invasive drug delivery method that is directly inserted into the skin without pain to improve the efficiency of transdermal administration and is a drug delivery system used to treat various diseases. Furthermore, nanoparticle (NP)-based drug delivery methods suggest therapeutic strategies to improve drug solubility and increase drug delivery efficiency. Therefore, the drug delivery system in which NPs and MNs are integrated is a promising alternative to the existing delivery methods of poorly soluble and hydrophobic drugs and nucleic acid therapeutics. This system can increase the solubility of drugs and biocompatibility in the body and improve the therapeutic efficacy with sustained drug release. In this review, we investigated recent studies of NPs designed for drug delivery, sustained-release drug delivery MNs based on these NPs, and the applications for clinical treatments.
微针（MN）是一种微创药物输送方法，直接插入皮肤而不会引起疼痛，以提高经皮给药的效率，是一种用于治疗各种疾病的药物输送系统。此外，基于纳米粒子（NP）的药物输送方法提出了治疗策略，以提高药物的溶解度并增加药物输送效率。因此，将 NPs 和 MN 集成的药物输送系统是改善难溶性和疏水性药物以及核酸治疗药物现有输送方法的有前途的替代方法。该系统可以提高药物在体内的溶解度和生物相容性，并通过持续释放药物来提高治疗效果。在这篇综述中，我们研究了用于药物输送的 NPs 的最新研究，基于这些 NPs 的缓释药物输送 MN 以及临床治疗的应用。
