Institute for Stem Cell Science and Regenerative Medicine (inStem), Bangalore, Karnataka 560065, India.
Department of Electronics Systems Engineering, Indian Institute of Science, Bangalore, Karnataka 560012, India.
Eur J Pharm Biopharm. 2021 Feb;159:151-169. doi: 10.1016/j.ejpb.2020.12.020. Epub 2020 Dec 31.
Sustained release of drugs over a pre-determined period is required to maintain an effective therapeutic dose for variety of drug delivery applications. Transdermal devices such as polymeric microneedle patches and other microneedle-based devices have been utilized for sustained release of their payload. Swift clearing of drugs can be prevented either by designing a slow-degrading polymeric matrix or by providing physiochemical triggers to different microneedle-based devices for on-demand release. These long-acting transdermal devices prevent the burst release of drugs. This review highlights the recent advances of microneedle-based devices for sustained release of vaccines, hormones, and antiretrovirals with their prospective safe clinical translation.
为了满足各种药物输送应用的需要，需要在预先确定的时间段内持续释放药物以维持有效的治疗剂量。透皮装置，如聚合物微针贴片和其他基于微针的装置，已被用于持续释放其有效载荷。通过设计缓慢降解的聚合物基质或为基于不同微针的装置提供物理化学触发因素来按需释放，可以防止药物迅速清除。这些长效透皮装置可防止药物的爆发释放。本综述重点介绍了基于微针的装置在疫苗、激素和抗逆转录病毒药物的持续释放方面的最新进展，及其有前景的安全临床转化。
