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阴道微生物群诊断在改善女性健康方面的未开发潜力。

The untapped potential of vaginal microbiome diagnostics for improving women's health.

作者信息

Da Silva Ana Sofia, Anwar Saba, Park Suenie, Park Sunwha, Goodfellow Laura, Sergaki Chrysi

机构信息

Department of Urogynaecology, King's College Hospital, London, United Kingdom.

Science and Research, Medicines and Healthcare Products Regulatory Agency, Potter's Bar, United Kingdom.

出版信息

Front Cell Infect Microbiol. 2025 Aug 7;15:1595182. doi: 10.3389/fcimb.2025.1595182. eCollection 2025.

Abstract

Microbiome research has expanded rapidly over the past 15 years; however, the primary focus has been on the gut microbiome. Although understudied, the vaginal microbiome holds significant potential to improve women's health. In this paper, we describe the current clinical diagnostic techniques utilised in women's health and examine their drawbacks and limitations. We also discuss emerging diagnostic technologies based on microbiome analysis that could enable greater precision in diagnosis and personalised treatment. We additionally emphasise the need for standardisation in microbiome analysis and strengthening the knowledge base to enable advancements in accurate diagnosis, ultimately improving patient outcomes. This article aims to highlight opportunities in the field that can transform women's health outcomes and outline the necessary actions to realise these opportunities, thereby enhancing women's lives.

摘要

在过去15年里,微生物组研究迅速发展;然而,主要关注点一直是肠道微生物组。尽管研究较少,但阴道微生物组在改善女性健康方面具有巨大潜力。在本文中,我们描述了目前用于女性健康的临床诊断技术,并审视了它们的缺点和局限性。我们还讨论了基于微生物组分析的新兴诊断技术,这些技术可以提高诊断的准确性和实现个性化治疗。我们还强调了微生物组分析标准化的必要性以及加强知识库以推动准确诊断的进步,最终改善患者的治疗效果。本文旨在突出该领域中能够改变女性健康结果的机会,并概述实现这些机会所需采取的必要行动,从而改善女性生活。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaea/12367778/582a64e9da1b/fcimb-15-1595182-g001.jpg

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