Pharmacology Laboratory, Faculty of Health Sciences, Universidad Científica del Sur; School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru.
Research Group "Investigación en Ciencias Básicas Estomatológicas (ICBEST)", Lima, Peru.
Indian J Dent Res. 2021 Oct-Dec;32(4):438-442. doi: 10.4103/ijdr.IJDR_977_20.
Oral administration of midazolam is one of the most important protocols for producing adequate conscious sedation; however, it has an unpleasant taste and is poorly tolerated by pediatric patients.
The aim of this study was to evaluate the sedative effect of diluted midazolam in different vehicles used to mask its unpleasant taste.
A total of 30 male mice (BALB-c) were randomly distributed in five groups. They were administered diluted midazolam in different vehicles (saline solution, paracetamol syrup, diclofenac suspension, multi-vitamin syrup, and boxed juice). All suspensions were administered orally (0.6 mg/Kg). The pH variation was evaluated with a digital pH meter, and the quality of sedation was evaluated in three tests: hole board test, grip strength test, and forced swimming test.
The paracetamol syrup vehicle was found to be the only vehicle which did not change its pH over time after dilution of midazolam. When evaluating the perforated platform, the greatest sedative effect was observed in the midazolam group with the paracetamol syrup (P > 0.05). Regarding grip strength, a difference was evident in all study groups at 45 minutes (P = 0.006); the midazolam group with the multi-vitamin syrup was less effective. Regarding the response time to forced swimming, the midazolam group with the paracetamol syrup presented the longest time at 15 and 30 minutes (5.39 ± 0.93 and 6.29 ± 0.83, respectively).
The suspension of midazolam diluted in the paracetamol syrup is the most suitable for performing conscious sedation efficiently.
口服咪达唑仑是产生充分意识镇静的最重要方案之一；然而，它的味道不好，儿科患者难以接受。
本研究旨在评估不同掩味载体稀释咪达唑仑的镇静效果。
30 只雄性小鼠（BALB-c）被随机分为五组。它们分别接受不同载体稀释的咪达唑仑（生理盐水、对乙酰氨基酚糖浆、双氯芬酸钠混悬剂、多种维生素糖浆和盒装果汁）口服给药（0.6mg/kg）。用数字 pH 计评估 pH 值变化，并用洞板试验、握力试验和强迫游泳试验评估镇静质量。
对乙酰氨基酚糖浆是唯一一种稀释咪达唑仑后 pH 值随时间变化不大的载体。在评估穿孔平台时，发现咪达唑仑与对乙酰氨基酚糖浆组的镇静作用最强（P＞0.05）。关于握力，所有研究组在 45 分钟时均有明显差异（P=0.006）；咪达唑仑与多种维生素糖浆组的效果较差。关于强迫游泳的反应时间，咪达唑仑与对乙酰氨基酚糖浆组在 15 和 30 分钟时的时间最长（分别为 5.39±0.93 和 6.29±0.83）。
稀释于对乙酰氨基酚糖浆的咪达唑仑混悬剂最适合有效进行清醒镇静。
