Roy Matrika Saha, Sarkar Bidduth Kumar, Kundu Sukalyan Kumar
Department of Pharmacy, Jahangirnagar University, Savar, Dhaka, Bangladesh.
Department of Pharmacy, Comilla University, Cumilla, Bangladesh.
Heliyon. 2024 Jul 2;10(13):e33929. doi: 10.1016/j.heliyon.2024.e33929. eCollection 2024 Jul 15.
Despite of being the drugs of the same therapeutic class (Benzodiazepines), each of them shows different actions prominently. It is commonly seen that Bromazepam, Clonazepam, and, Alprazolam are prescribed for the treatment of anxiety disorders, panic disorders, and phobias. On the other hand, Midazolam, Temazepam, Flurazepam, and Nitrazepam are indicated for the treatment of insomnia and Lorazepam is considered as a drug having anticonvulsant effects. As the mechanism of action is the same, there should be some differences in the binding patterns with the proteins that create differences in their impacts on the body. A deep screening of the binding patterns of the available Benzodiazepines in the market to the GABA receptor will be beneficial to find out the responsible amino acids for being accountable for showing any specific action. This reveal will help design new molecules with the highest beneficial effect and lowest toxicity in the body. The method provides the initial level of understanding regarding the binding patterns, performing in vitro and in vivo experiments will be more specific to claim the benefits of newly designed drugs.
尽管它们属于同一治疗类别（苯二氮䓬类药物），但每种药物都有显著不同的作用。常见的情况是，溴西泮、氯硝西泮和阿普唑仑被用于治疗焦虑症、恐慌症和恐惧症。另一方面，咪达唑仑、替马西泮、氟西泮和硝西泮用于治疗失眠，而劳拉西泮被认为是一种具有抗惊厥作用的药物。由于作用机制相同，它们与蛋白质的结合模式应该存在一些差异，这导致它们对身体的影响有所不同。深入筛选市场上现有苯二氮䓬类药物与GABA受体的结合模式，将有助于找出对表现出任何特定作用负责的氨基酸。这一发现将有助于设计出在体内具有最高有益效果和最低毒性的新分子。该方法提供了关于结合模式的初步理解水平，进行体外和体内实验将更具体地证明新设计药物的益处。
