School of Pharmacy, Pacific University Oregon, Hillsboro, OR 97123, USA.
Med Sci (Basel). 2022 Apr 22;10(2):24. doi: 10.3390/medsci10020024.
Parasites of the genus cause a variety of devastating and often fatal diseases in humans and domestic animals worldwide. The need for new therapeutic strategies is urgent because no vaccine is available, and treatment options are limited due to a lack of specificity and the emergence of drug resistance. Polyamines are metabolites that play a central role in rapidly proliferating cells, and recent studies have highlighted their critical nature in . Numerous studies using a variety of inhibitors as well as gene deletion mutants have elucidated the pathway and routes of transport, revealing unique aspects of polyamine metabolism in parasites. These studies have also shed light on the significance of polyamines for parasite proliferation, infectivity, and host-parasite interactions. This comprehensive review article focuses on the main polyamine biosynthetic enzymes: ornithine decarboxylase, -adenosylmethionine decarboxylase, and spermidine synthase, and it emphasizes recent discoveries that advance these enzymes as potential therapeutic targets against parasites.
属寄生虫会导致全世界人类和家养动物患上多种毁灭性且往往致命的疾病。由于没有疫苗，而且由于缺乏特异性和耐药性的出现，治疗选择有限，因此迫切需要新的治疗策略。多胺是在快速增殖细胞中起核心作用的代谢物，最近的研究强调了它们在寄生虫中的关键性质。许多使用各种抑制剂和基因缺失突变体的研究阐明了途径和运输途径，揭示了寄生虫中多胺代谢的独特方面。这些研究还揭示了多胺对寄生虫增殖、感染力和宿主-寄生虫相互作用的重要性。这篇全面的综述文章重点介绍了主要的多胺生物合成酶：鸟氨酸脱羧酶、-腺苷甲硫氨酸脱羧酶和精脒合酶，并强调了最近的发现，这些发现将这些酶作为针对寄生虫的潜在治疗靶点。
