Swanson Gregory P, Hammonds Kendall, Jhavar Sameer
Baylor Scott and White Health, Temple, TX 76508, USA.
Hematol Rep. 2022 May 12;14(2):155-164. doi: 10.3390/hematolrep14020023.
Introduction: There are few reports on the effect of radiation alone on blood cells (without chemotherapy). We sought to develop a single source as a reference. Materials and Methods: For over 300 prostate cancer patients treated with radiation alone, we collected the baseline, end-of-treatment and three-month post-therapy complete blood counts (CBC). Results: The hemoglobin dropped by a mean of 1.00 g/dL (−7.1%), with an RBC count of 0.40 × 1012 (−8.6%) at the end of treatment and remained significantly (but <5%) below baseline at follow-up. Significant declines were seen in the levels of the granulocytes (−12.2%; −0.67 × 109), monocytes (−2.2%; −0.05 × 109) and platelets (−12.7%; −30.31 × 109) at the end of treatment, but all returned to baseline on follow-up. The neutrophils and basophils (the primary components of the granulocytes) suffered a significant decline but returned to baseline by the follow-up. The other granulocyte components, the eosinophils, did not decline significantly. The most dramatic decline was in the levels of lymphocytes −62.5% (−1.29 × 109), which were still significantly below baseline (−38%) after two years. Conclusion: The effect of radiation is mostly transitory, with some persistence in hemoglobin/erythrocyte levels (<5%). Lymphocytes are slower to recover, remaining significantly below baseline after two years. It is noteworthy that of the patients whose lymphocytes were in the normal range at the start of therapy, only 14% were below normal at follow-up. Radiation alone has negligible-to-modest long-term effects on blood counts.
关于单纯放疗（不联合化疗）对血细胞影响的报道较少。我们试图建立一个单一来源作为参考。材料与方法：对于300多名仅接受放疗的前列腺癌患者，我们收集了基线、治疗结束时及治疗后三个月的全血细胞计数（CBC）。结果：血红蛋白平均下降1.00 g/dL（-7.1%），治疗结束时红细胞计数为0.40×10¹²（-8.6%），随访时仍显著低于基线水平（但<5%）。治疗结束时粒细胞水平（-12.2%；-0.67×10⁹）、单核细胞水平（-2.2%；-0.05×10⁹）和血小板水平（-12.7%；-30.31×10⁹）均显著下降，但随访时均恢复至基线水平。中性粒细胞和嗜碱性粒细胞（粒细胞的主要成分）显著下降，但随访时恢复至基线水平。粒细胞的其他成分嗜酸性粒细胞未显著下降。最显著的下降是淋巴细胞水平下降62.5%（-1.29×10⁹），两年后仍显著低于基线水平（-38%）。结论：放疗的影响大多是暂时的，血红蛋白/红细胞水平有一定程度的持续下降（<5%）。淋巴细胞恢复较慢，两年后仍显著低于基线水平。值得注意的是，治疗开始时淋巴细胞在正常范围内的患者，随访时只有14%低于正常水平。单纯放疗对血细胞计数的长期影响可忽略不计至适度。
