Lima Priscila A, Berg Bárbara B, Castor Marina Gomes Miranda E
Department of Pharmacology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Graduate Program in Physiology and Pharmacology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Intest Res. 2022 Oct;20(4):392-417. doi: 10.5217/ir.2021.00160. Epub 2022 May 31.
The components of the endogenous cannabinoid system are widely expressed in the gastrointestinal tract contributing to local homeostasis. In general, cannabinoids exert inhibitory actions in the gastrointestinal tract, inducing anti-inflammatory, antiemetic, antisecretory, and antiproliferative effects. Therefore, cannabinoids are interesting pharmacological compounds for the treatment of several acute intestinal disorders, such as dysmotility, emesis, and abdominal pain. Likewise, the role of cannabinoids in the treatment of chronic intestinal diseases, such as irritable bowel syndrome and inflammatory bowel disease, is also under investigation. Patients with chronic intestinal inflammatory diseases present impaired quality of life, and mental health issues are commonly associated with long-term chronic diseases. The complex pathophysiology of these diseases contributes to difficulties in diagnosis and, therefore, in the choice of a satisfactory treatment. Thus, this article reviews the involvement of the cannabinoid system in chronic inflammatory diseases that affect the gastrointestinal tract and highlights possible therapeutic approaches related to the use of cannabinoids.
内源性大麻素系统的组成部分在胃肠道中广泛表达，有助于局部内环境稳定。一般来说，大麻素在胃肠道中发挥抑制作用，诱导抗炎、止吐、抗分泌和抗增殖作用。因此，大麻素是治疗几种急性肠道疾病（如动力障碍、呕吐和腹痛）的有趣药理化合物。同样，大麻素在治疗慢性肠道疾病（如肠易激综合征和炎症性肠病）中的作用也在研究中。患有慢性肠道炎症性疾病的患者生活质量受损，心理健康问题通常与长期慢性病相关。这些疾病复杂的病理生理学导致诊断困难，因此也难以选择令人满意的治疗方法。因此，本文综述了大麻素系统在影响胃肠道的慢性炎症性疾病中的作用，并强调了与使用大麻素相关的可能治疗方法。
