Balsiger Fabian, Wagner Benedikt, Jende Johann M E, Marty Benjamin, Bendszus Martin, Scheidegger Olivier, Kurz Felix T
Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Methods Protoc. 2022 May 6;5(3):39. doi: 10.3390/mps5030039.
Magnetic resonance neurography (MRN), the MR imaging of peripheral nerves, is clinically used for assessing and monitoring peripheral neuropathies based on qualitative, weighted MR imaging. Recently, quantitative MRN has been increasingly reported with various MR parameters as potential biomarkers. An evidence synthesis mapping the available methodologies and normative values of quantitative MRN of human peripheral nerves, independent of the anatomical location and type of neuropathy, is currently unavailable and would likely benefit this young field of research. Therefore, the proposed scoping review will include peer-reviewed literature describing methodologies and normative values of quantitative MRN of human peripheral nerves. The literature search will include the databases MEDLINE (PubMed), EMBASE (Ovid), Web of Science, and Scopus. At least two independent reviewers will screen the titles and abstracts against the inclusion criteria. Potential studies will then be screened in full against the inclusion criteria by two or more independent reviewers. From all eligible studies, data will be extracted by two or more independent reviewers and presented in a diagrammatic or tabular form, separated by MR parameter and accompanied by a narrative summary. The reporting will follow the guidelines of the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). Upon completion, the scoping review will provide a map of the available literature, identify possible gaps, and inform on possible future research. SCOPING REVIEW REGISTRATION: Open Science Framework 9P3ZM.
磁共振神经成像（MRN），即外周神经的磁共振成像，临床上基于定性加权磁共振成像用于评估和监测外周神经病变。最近，越来越多关于定量MRN的报道将各种磁共振参数作为潜在的生物标志物。目前尚缺乏一份证据综述来梳理人类外周神经定量MRN的可用方法和规范值，且不受神经病变的解剖位置和类型限制，而这可能会使这个年轻的研究领域受益。因此，拟议的范围综述将纳入描述人类外周神经定量MRN方法和规范值的同行评审文献。文献检索将包括MEDLINE（PubMed）、EMBASE（Ovid）、科学网和Scopus数据库。至少两名独立评审员将根据纳入标准筛选标题和摘要。然后，两名或更多独立评审员将根据纳入标准对潜在研究进行全文筛选。从所有符合条件的研究中，两名或更多独立评审员将提取数据，并以图表或表格形式呈现，按磁共振参数分类，同时附上叙述性总结。报告将遵循《系统评价和Meta分析扩展的范围综述首选报告项目指南》（PRISMA-ScR）。完成后，范围综述将提供现有文献的图谱，识别可能的空白，并为未来可能的研究提供信息。范围综述注册：开放科学框架9P3ZM。
