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双极射频膝神经切断术治疗膝关节骨关节炎所致慢性疼痛

Bipolar Radiofrequency Neurotomy of the Genicular Nerves for Chronic Pain Due to Knee Osteoarthritis.

作者信息

Singh Jaspal R, Kwon Susie S, Schirripa Frank V, Habibi Behnum A, Rand Ethan

机构信息

Department of Rehabilitation Medicine, Weill Cornell Medicine, New York, NY, USA.

Department of Rehabilitation Medicine, New York-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA.

出版信息

HSS J. 2022 May;18(2):229-234. doi: 10.1177/15563316211040416. Epub 2021 Sep 4.

Abstract

The current treatments for chronic knee osteoarthritis (OA), a disabling and costly healthcare condition in the United States, vary in their level of supporting evidence. Although total knee replacement is one of the best-supported interventions, its associated risks should not be taken lightly, especially in older patients with comorbidities. Genicular nerve block with subsequent genicular nerve radiofrequency neurotomy (GN-RFN) has emerged as a promising intervention for refractory pain in knee OA. We sought to assess the pain and functional outcomes of genicular nerve bipolar radiofrequency neurotomy (B-RFN) for the treatment of chronic pain due to knee OA. A total of 21 patients who underwent unilateral genicular nerve B-RFN after positive diagnostic genicular nerve block (50% or greater pain relief) treated between July 2018 to December 2018 were included. Pain numeric rating scale (NRS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were collected at baseline, 3 months, and 6 months post-B-RFN. Changes at each time point were compared to baseline scores using paired sample tests. At 3 months, 62% of patients had a greater than 50% improvement in NRS scores and 57% of patients had a greater than 50% improvement in WOMAC scores. At 6 months, 81% of patients had a greater than 50% improvement in NRS scores and 67% had a greater than 50% improvement in WOMAC scores. The absolute change in mean NRS (± standard deviation) at 6 months went from 7.5 ± 1.9 to 2.5 ± 1.2. The absolute change in mean WOMAC scores at 6 months went from 46.9 ± 8.0 to 19.0 ± 6.2. Of 21 patients, 14 (67%) saw greater than 50% improvements in both NRS and WOMAC scores at 6 months after genicular nerve B-RFN. Further prospective studies are needed to determine the selection criteria of patients most likely to benefit from this procedure.

摘要

慢性膝关节骨关节炎(OA)是美国一种导致残疾且医疗成本高昂的疾病,目前针对它的治疗方法,其支持证据的水平各不相同。尽管全膝关节置换术是最有充分证据支持的干预措施之一,但其相关风险不容忽视,尤其是在患有合并症的老年患者中。膝状神经阻滞联合后续的膝状神经射频神经切断术(GN-RFN)已成为治疗膝关节OA难治性疼痛的一种有前景的干预方法。我们试图评估膝状神经双极射频神经切断术(B-RFN)治疗膝关节OA所致慢性疼痛的疼痛和功能结局。纳入了2018年7月至2018年12月期间,在诊断性膝状神经阻滞阳性(疼痛缓解50%或更多)后接受单侧膝状神经B-RFN治疗的21例患者。在B-RFN术后基线、3个月和6个月时收集疼痛数字评定量表(NRS)和西安大略和麦克马斯特大学骨关节炎指数(WOMAC)评分。使用配对样本检验将每个时间点的变化与基线评分进行比较。在3个月时,62%的患者NRS评分改善超过50%,57%的患者WOMAC评分改善超过50%。在6个月时,81%的患者NRS评分改善超过50%,67%的患者WOMAC评分改善超过50%。6个月时平均NRS(±标准差)的绝对变化从7.5±1.9降至2.5±1.2。6个月时平均WOMAC评分的绝对变化从46.9±8.0降至19.0±6.2。在21例患者中,14例(67%)在膝状神经B-RFN术后6个月时NRS和WOMAC评分均改善超过50%。需要进一步的前瞻性研究来确定最有可能从该手术中获益的患者的选择标准。

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