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益气活血通络汤对糖尿病性神经病理性疼痛大鼠脊髓小胶质细胞活化及ASK1-MKK3-p38信号通路的影响

The Effect of Yiqi Huoxue Tongluo Decoction on Spinal Cord Microglia Activation and ASK1-MKK3-p38 Signal Pathway in Rats with Diabetic Neuropathic Pain.

作者信息

Wang Fanjing, Tang Heyong, Ma Junlong, Cheng Lianzhi, Lin Yixuan, Zhao Jindong, Shen Guoming, Fang Zhaohui, Jiang Aijuan

机构信息

Department of Endocrine, First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China.

School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, China.

出版信息

Evid Based Complement Alternat Med. 2022 May 19;2022:2408265. doi: 10.1155/2022/2408265. eCollection 2022.

DOI:10.1155/2022/2408265
PMID:35646150
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9135525/
Abstract

Diabetic neuropathic pain (DNP) is one of the most common chronic peripheral neuropathies in diabetes mellitus (DM). . To observe the underlying mechanism of the effects of Yiqi Huoxue Tongluo Decoction (YQHX) on DNP rats. . SD rats were intraperitoneally injected with 35 mg/kg streptozotocin (STZ) to prepare DNP models and were treated with YQHX for 8 weeks. . Studies have shown that the drug restores some levels of MWT, TWL, and MNCV, downregulates the levels of inflammatory factors IL-6, IL-1, and TNF-, downregulates the levels of ASK1-MKK3-p38, and weakens the level of OX42 activation. . Yiqi Huoxue Tongluo Decoction can relieve DNP by affecting the activity of spinal cord microglia and the ASK1-MKK3-p38 signaling pathway, thereby reducing the central sensitization caused by the inflammatory response of DNP rats.

摘要

糖尿病性神经病理性疼痛（DNP）是糖尿病（DM）最常见的慢性周围神经病变之一。为观察益气活血通络汤（YQHX）对DNP大鼠影响的潜在机制。将SD大鼠腹腔注射35mg/kg链脲佐菌素（STZ）制备DNP模型，并用YQHX治疗8周。研究表明，该药物可恢复一定水平的机械缩足阈值（MWT）、热缩足潜伏期（TWL）和运动神经传导速度（MNCV），下调炎症因子白细胞介素-6（IL-6）、白细胞介素-1（IL-1）和肿瘤坏死因子-α（TNF-α）的水平，下调凋亡信号调节激酶1（ASK1）-丝裂原活化蛋白激酶激酶3（MKK3）-p38的水平，并减弱补体C3b受体相关蛋白（OX42）的活化水平。益气活血通络汤可通过影响脊髓小胶质细胞的活性和ASK1-MKK3-p38信号通路来缓解DNP，从而减轻DNP大鼠炎症反应引起的中枢敏化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5177/9135525/ed9524f1847e/ECAM2022-2408265.009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5177/9135525/f203326a1604/ECAM2022-2408265.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5177/9135525/de8c933254f3/ECAM2022-2408265.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5177/9135525/fea9247b66b9/ECAM2022-2408265.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5177/9135525/885d8e44f573/ECAM2022-2408265.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5177/9135525/49ffe50674da/ECAM2022-2408265.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5177/9135525/59baeeaba480/ECAM2022-2408265.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5177/9135525/99ea218a982e/ECAM2022-2408265.007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5177/9135525/ed9524f1847e/ECAM2022-2408265.009.jpg

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