Department of Pathology, College of Medicine, Babylon University, Babylon, Iraq.
J Med Life. 2022 Apr;15(4):504-508. doi: 10.25122/jml-2021-0272.
Prostatic adenocarcinoma is the second-most common cancer in men and the fifth most common cause of cancer death. Its incidence increases with age; 75% of patients are 65 years and older. The aim of the study was to assess epithelial membrane antigen (EMA) expression in prostatic adenocarcinoma as a poor prognostic marker and its correlation to some pathological parameters. The formalin-fixed, paraffin-surrounded tissue blocks were retrospectively collected from 40 men diagnosed with prostate carcinoma. All cases were collected from Al Hilla Teaching Hospital and some private labs between October 2018 - November 2020, with ages ranging from 30-89 years. Statistical analysis was done using SPSS 22, frequency and percentage were used for categorical data, and Chi-square was used to evaluate connotation between variables. P-value ≤0.05 was significant. The blocks were sectioned for EMA immunohistochemical staining using monoclonal mouse anti-human EMA protein. EMA protein overexpression was detected in 75% (n=30/40) of prostatic adenocarcinoma cases. EMA expression showed no correlation with the patient's age (P=0.09) and a positive correlation with the cancer grade (P=0.003). In prostatic adenocarcinoma patients, EMA could be seen as a potential prognostic predictor for disease progression.
前列腺腺癌是男性第二大常见癌症，也是第五大常见癌症死亡原因。其发病率随年龄增长而增加；75%的患者年龄在 65 岁及以上。本研究旨在评估前列腺腺癌中上皮膜抗原（EMA）的表达作为不良预后标志物及其与某些病理参数的相关性。从 2018 年 10 月至 2020 年 11 月期间，在 Al Hilla 教学医院和一些私人实验室诊断为前列腺癌的 40 名男性中，回顾性收集了福尔马林固定、石蜡包埋的组织块。所有病例的年龄均在 30-89 岁之间。使用 SPSS 22 进行统计分析，使用分类数据的频率和百分比，卡方检验用于评估变量之间的内涵。P 值≤0.05 为显著。使用单克隆鼠抗人 EMA 蛋白对组织块进行 EMA 免疫组织化学染色。在 75%（n=30/40）的前列腺腺癌病例中检测到 EMA 蛋白过表达。EMA 表达与患者年龄（P=0.09）无相关性，与癌症分级呈正相关（P=0.003）。在前列腺腺癌患者中，EMA 可被视为疾病进展的潜在预后预测因子。
