Modeling photoacoustic pressure generation in colloidal suspensions at different volume fractions based on a multi-scale approach.

Further development of quantitative photoacoustic tomography requires understanding the photoacoustic pressure generation by modeling the generation process. This study modeled the initial photoacoustic pressure in colloidal suspensions, used as tissue phantoms, at different volume fractions on a multi-scale approach. We modeled the thermodynamic and light scattering properties on a microscopic scale with/without treating the hard-sphere interaction between colloidal particles. Meanwhile, we did the light energy density on a macroscopic scale. We showed that the hard-sphere interaction significantly influences the initial pressure and related quantities at a high volume fraction except for the thermodynamic properties. We also showed the initial pressure at the absorber inside the medium logarithmically decreases with increasing the volume fractions. This result is mainly due to the decay of the light energy density with light scattering. Our numerical results suggest that modeling light scattering and propagation is crucial over modeling thermal expansion.