文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

长链非编码RNA-AC099850.3的过表达与肺腺癌的肿瘤进展和不良预后相关。

Over-Expression of Long Non-Coding RNA-AC099850.3 Correlates With Tumor Progression and Poor Prognosis in Lung Adenocarcinoma.

作者信息

Chen Xi, Guo Jishu, Zhou Fan, Ren Wenjun, Pu Jun, Mutti Luciano, Niu Xiaoqun, Jiang Xiulin

机构信息

Department of Neurosurgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, China.

Institute for Ecological Research and Pollution Control of Plateau Lakes, School of Ecology and Environmental Science, Yunnan University, Kunming, China.

出版信息

Front Oncol. 2022 May 11;12:895708. doi: 10.3389/fonc.2022.895708. eCollection 2022.

DOI:10.3389/fonc.2022.895708
PMID:35646670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9132095/
Abstract

Lung adenocarcinoma (LUAD) is the most common histological lung cancer, and it is the leading cause of cancer-related deaths worldwide. Long noncoding RNAs (lncRNAs) have been implicated in the initiation and progression of various cancers. LncRNA-AC099850.3 is a novel lncRNA that is abnormally expressed in diverse cancer types including LUAD. However, the clinical significance, prognostic value, diagnostic value, immune role, and potential biological function of AC099850.3 LUAD remain elusive. In this study, we found that AC099850.3 was highly expressed in LUAD and associated with an advanced tumor stage, poor prognosis, and immune infiltration. Receiver operating curve analysis revealed the significant diagnostic ability of AC099850.3 (AUC=0.888). Functionally, the knockdown of AC099850.3 restrained LUAD cell proliferation and migration . Finally, we constructed a competitive endogenous RNAs (ceRNA) network that included hsa-miR-101-3p and 4 mRNAs (ESPL1, AURKB, BUB3, and FAM83D) specific to AC099850.3 in LUAD. Kaplan-Meier survival analysis showed that a lower expression of miR-101-3p and a higher expression of ESPL1, AURKB, BUB3, and FAM83D, were associated with adverse clinical outcomes in patients with LUAD. This finding provided a comprehensive view of the AC099850.3-mediated ceRNA network in LUAD, thereby highlighting its potential role in the diagnosis and prognosis of LUAD.

摘要

肺腺癌（LUAD）是最常见的组织学类型肺癌，也是全球癌症相关死亡的主要原因。长链非编码RNA（lncRNAs）已被证明与多种癌症的发生和发展有关。LncRNA-AC099850.3是一种新型lncRNA，在包括LUAD在内的多种癌症类型中异常表达。然而，AC099850.3在LUAD中的临床意义、预后价值、诊断价值、免疫作用及潜在生物学功能仍不清楚。在本研究中，我们发现AC099850.3在LUAD中高表达，且与肿瘤晚期、预后不良及免疫浸润相关。受试者工作特征曲线分析显示AC099850.3具有显著的诊断能力（AUC=0.888）。功能上，敲低AC099850.3可抑制LUAD细胞增殖和迁移。最后，我们构建了一个竞争性内源性RNA（ceRNA）网络，该网络包含hsa-miR-101-3p和4种LUAD中AC099850.3特异的mRNA（ESPL1、AURKB、BUB3和FAM83D）。Kaplan-Meier生存分析表明，miR-101-3p低表达以及ESPL1、AURKB、BUB3和FAM83D高表达与LUAD患者不良临床结局相关。这一发现全面揭示了LUAD中AC099850.3介导的ceRNA网络，从而突出了其在LUAD诊断和预后中的潜在作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/9acc54a7b5ee/fonc-12-895708-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/1187406a53c8/fonc-12-895708-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/7adc20b36a3c/fonc-12-895708-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/18a47ccb9efe/fonc-12-895708-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/50c9deb01e8f/fonc-12-895708-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/e6dd570630a5/fonc-12-895708-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/07826d216332/fonc-12-895708-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/b464b3a7f24c/fonc-12-895708-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/90b72cd20f57/fonc-12-895708-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/d95c456c701f/fonc-12-895708-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/91ea9d10477b/fonc-12-895708-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/9acc54a7b5ee/fonc-12-895708-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/1187406a53c8/fonc-12-895708-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/7adc20b36a3c/fonc-12-895708-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/18a47ccb9efe/fonc-12-895708-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/50c9deb01e8f/fonc-12-895708-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/e6dd570630a5/fonc-12-895708-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/07826d216332/fonc-12-895708-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/b464b3a7f24c/fonc-12-895708-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/90b72cd20f57/fonc-12-895708-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/d95c456c701f/fonc-12-895708-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/91ea9d10477b/fonc-12-895708-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6885/9132095/9acc54a7b5ee/fonc-12-895708-g011.jpg

相似文献

[1]
Over-Expression of Long Non-Coding RNA-AC099850.3 Correlates With Tumor Progression and Poor Prognosis in Lung Adenocarcinoma.

Front Oncol. 2022-5-11

[2]
Comprehensive analysis of co-expressed genes with TDP-43: prognostic and therapeutic potential in lung adenocarcinoma.

J Cancer Res Clin Oncol. 2024-1-28

[3]
Construction of a prognostic model for lung adenocarcinoma based on necroptosis genes and its exploration of the potential for tumor immunotherapy.

Transl Cancer Res. 2025-5-30

[4]
Systematic pan-cancer analysis identified NCOA4 as an immunological and prognostic biomarker and validated in lung adenocarcinoma.

Discov Oncol. 2025-7-28

[5]
Construction of an EMT-related lncRNA prognostic signature for lung adenocarcinoma and functional verification of its hub gene LINC01615.

J Cancer Res Clin Oncol. 2023-12

[6]
Identification and Validation of lncRNA-AC087588.2 in Lung Adenocarcinoma: A Novel Prognostic and Diagnostic Indicator.

Front Mol Biosci. 2022-6-13

[7]
A novel copper-induced cell death-related lncRNA prognostic signature associated with immune infiltration and clinical value in gastric cancer.

J Cancer Res Clin Oncol. 2023-9

[8]
Caveolin-1 inhibits the proliferation and invasion of lung adenocarcinoma via EGFR degradation.

Sci Rep. 2025-7-1

[9]
Machine learning-based immune prognostic model and ceRNA network construction for lung adenocarcinoma.

J Cancer Res Clin Oncol. 2023-8

[10]
Molecular subtypes of lung adenocarcinoma patients for prognosis and therapeutic response prediction with machine learning on 13 programmed cell death patterns.

J Cancer Res Clin Oncol. 2023-10

引用本文的文献

[1]
Construction of a prognostic model for lung adenocarcinoma based on necroptosis genes and its exploration of the potential for tumor immunotherapy.

Transl Cancer Res. 2025-5-30

[2]
A seven-LncRNA signature for prognosis prediction of patients with lung squamous cell carcinoma through tumor immune escape.

Front Oncol. 2025-3-24

[3]
Identification of a long non-coding RNA signature associated with cuproptosis for prognosis and immunotherapy response prediction in patients with lung adenocarcinoma.

Discov Oncol. 2025-3-31

[4]
Identification and validation of a five-necroptosis-related lncRNAs signature for prognostic prediction in hepatocellular carcinoma.

Heliyon. 2024-9-6

[5]
AC099850.3 promotes HBV-HCC cell proliferation and invasion through regulating CD276: a novel strategy for sorafenib and immune checkpoint combination therapy.

J Transl Med. 2024-8-31

[6]
Identification of a novel necroptosis-related LncRNA signature for prognostic prediction and immune response in oral squamous cell carcinoma.

Cancer Biomark. 2024

[7]
Programmed cell death-ligand 2: new insights in cancer.

Front Immunol. 2024

[8]
LncRNAs in non-small cell lung cancer: novel diagnostic and prognostic biomarkers.

Front Mol Biosci. 2023-12-13

[9]
Identification and validation of a novel cuproptosis-related lncRNA signature for predicting colorectal cancer patients' survival.

J Gastrointest Oncol. 2023-4-29

[10]
Machine learning-based construction of a ferroptosis and necroptosis associated lncRNA signature for predicting prognosis and immunotherapy response in hepatocellular cancer.

Front Oncol. 2023-4-20

本文引用的文献

[1]
Long non-coding RNA LINC00680 functions as a ceRNA to promote esophageal squamous cell carcinoma progression through the miR-423-5p/PAK6 axis.

Mol Cancer. 2022-3-7

[2]
Comprehensive Pan-Cancer Analysis of the Prognostic and Immunological Roles of the METTL3/lncRNA-SNHG1/miRNA-140-3p/UBE2C Axis.

Front Cell Dev Biol. 2021-11-10

[3]
Expression and clinical significance of AURKB gene in lung adenocarcinoma: Analysis based on the data-mining of bioinformatic database.

Medicine (Baltimore). 2021-8-6

[4]
Linc8087 predicts favorable prognosis and inhibits cell migration and invasion in NSCLC.

Pathol Res Pract. 2021-9

[5]
miR-101-3p Serves as a Tumor Suppressor for Renal Cell Carcinoma and Inhibits Its Invasion and Metastasis by Targeting EZH2.

Biomed Res Int. 2021

[6]
LncRNA AC079630.4 expression associated with the progression and prognosis in lung cancer.

Aging (Albany NY). 2021-7-19

[7]
LncRNA MCM3AP-AS1 sponges miR-148a to enhance cell invasion and migration in small cell lung cancer.

BMC Cancer. 2021-7-16

[8]
LncRNA NORAD, sponging miR-363-3p, promotes invasion and EMT by upregulating PEAK1 and activating the ERK signaling pathway in NSCLC cells.

J Bioenerg Biomembr. 2021-6

[9]
miR-101-3p sensitizes lung adenocarcinoma cells to irradiation via targeting BIRC5.

Oncol Lett. 2021-4

[10]
Role of lncRNA LUCAT1 in cancer.

Biomed Pharmacother. 2021-2

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索