Division of Pulmonary Medicine, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Front Public Health. 2022 May 13;10:872220. doi: 10.3389/fpubh.2022.872220. eCollection 2022.
Smoking behavior differs between the sexes. Weight control is one of the main reasons leading to tobacco abuse in women but not in men. Studies on the predictive factors of cessation failure between sexes are scarce. This study is aim to investigate whether there are sex differences in the effect of weight gain on smoking cessation rate.
Participants in the smoking-cessation program at a Medical Center in Taiwan between 2018 and 2019 were included. Details of age, sex, comorbidities, depression screening, nicotine dependence, body weight, and cessation medications of the participants were collected. The participants were classified based on their sex, and multivariable logistic regression analyses were conducted. Multivariable logistic regression analyses were performed for sensitivity analysis after stratifying the participants according to their weight loss (weight loss ≥ 1.5 kg and weight loss ≥ 3.0 kg).
A total of 1,475 participants were included. The body-weight gain in women was associated with failed abstinence (adjusted odds ratio (OR): 3.10, 95% CI: 1.10-9.04). In contrast, body-weight gain in men was associated with successful 6-month prolonged abstinence (adjusted OR: 0.77, 95% CI: 0.61-0.98). The adjusted ORs for any body-weight loss, body-weight loss ≥1.5 kg, and body-weight loss ≥3.0 kg were 0.28 (95% CI: 0.09-0.88), 0.14 (95% CI: 0.03-0.55), and 0.03 (95% CI: 0.01-0.42), respectively.
Body-weight gain in women during a hospital-based smoking-cessation program is associated with abstinence failure. Further multicenter studies, including participants of different races and cultural backgrounds, are warranted.
吸烟行为在性别之间存在差异。控制体重是导致女性而非男性滥用烟草的主要原因之一。关于性别之间戒烟失败预测因素的研究很少。本研究旨在探讨体重增加对戒烟成功率的影响是否存在性别差异。
纳入 2018 年至 2019 年在台湾一家医疗中心参加戒烟计划的参与者。收集参与者的年龄、性别、合并症、抑郁筛查、尼古丁依赖、体重和戒烟药物使用情况等详细信息。根据性别对参与者进行分类，并进行多变量逻辑回归分析。根据体重减轻（体重减轻≥1.5 公斤和体重减轻≥3.0 公斤）对参与者进行分层后，进行多变量逻辑回归分析敏感性分析。
共纳入 1475 名参与者。女性体重增加与戒烟失败相关（调整后的优势比（OR）：3.10，95%可信区间（CI）：1.10-9.04）。相比之下，男性体重增加与 6 个月的持续戒烟成功相关（调整后的 OR：0.77，95%CI：0.61-0.98）。任何体重减轻、体重减轻≥1.5 公斤和体重减轻≥3.0 公斤的调整后的 OR 分别为 0.28（95%CI：0.09-0.88）、0.14（95%CI：0.03-0.55）和 0.03（95%CI：0.01-0.42）。
在医院戒烟计划中，女性体重增加与戒烟失败相关。需要进行包括不同种族和文化背景参与者的多中心研究。
