Kaibuchi Nobuyuki, Iwata Takanori, Koga Yoko Kawase, Okamoto Toshihiro
Department of Oral and Maxillofacial Surgery, Tokyo Women's Medical University School of Medicine, Shinjuku, Japan.
Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), Tokyo, Japan.
Front Bioeng Biotechnol. 2022 May 12;10:902349. doi: 10.3389/fbioe.2022.902349. eCollection 2022.
Despite medication-related osteonecrosis of the jaw (MRONJ) being first reported in 2003, the optimal treatment and prevention modalities for MRONJ are not clear. As a result, dentistry, oral surgery, and departments involved in the treatment of cancer and bone diseases are struggling with the management of MRONJ. Several cases of MRONJ cannot be managed by conventional treatment strategies recommended in various position papers. Therefore, studies have been conducted to investigate the efficacy of novel therapies for MRONJ. However, the optimal treatment is unknown. Several cell therapies including autologous cell transplantation have been reported for MRONJ. Although the efficacy of cell therapy for MRONJ has been demonstrated, large, statistically accurate clinical trials are lacking. We have been investigating the efficacy of MRONJ treatment using mesenchymal stromal cell (MSC) sheets since 2013 and confirmed its efficacy through various experiments, wherein MSC sheets were transplanted in model rats and beagle dogs with MRONJ-like lesions. Based on these results, we are planning to conduct a clinical trial of MRONJ therapy using periodontal ligament-derived MSC sheets.
尽管颌骨药物性骨坏死（MRONJ）于2003年首次被报道，但MRONJ的最佳治疗和预防方式仍不明确。因此，牙科、口腔外科以及参与癌症和骨疾病治疗的科室都在为MRONJ的管理而苦苦挣扎。一些MRONJ病例无法通过各种立场文件中推荐的传统治疗策略进行处理。因此，已经开展了多项研究来探究MRONJ新疗法的疗效。然而，最佳治疗方法尚不清楚。包括自体细胞移植在内的几种细胞疗法已被报道用于治疗MRONJ。尽管细胞疗法对MRONJ的疗效已得到证实，但缺乏大规模、统计学上准确的临床试验。自2013年以来，我们一直在研究使用间充质基质细胞（MSC）片治疗MRONJ的疗效，并通过各种实验证实了其疗效，其中将MSC片移植到患有类MRONJ病变的模型大鼠和比格犬体内。基于这些结果，我们计划开展一项使用牙周膜来源的MSC片治疗MRONJ的临床试验。
