• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

1例罕见的与牙科种植体相关的贝伐单抗相关性颌骨坏死病例。

A rare case of bevacizumab-related osteonecrosis of the jaw associated with dental implants.

作者信息

Maluf Gustavo, Caldas Rogério Jardim, Fregnani Eduardo Rodrigues, da Silva Santos Paulo Sérgio

机构信息

Private Clinic, Brasília, DF, Brazil.

, Brasília, Brasil.

出版信息

Int J Implant Dent. 2019 Oct 1;5(1):34. doi: 10.1186/s40729-019-0188-0.

DOI:10.1186/s40729-019-0188-0
PMID:31571065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6768921/
Abstract

BACKGROUND

Medication-related osteonecrosis of the jaw (MRONJ) is characterized by the development of bone necrosis in the jaws of patients receiving antiresorptive and/or antiangiogenic medications. No scientific reports have been published yet on bevacizumab-related osteonecrosis of the jaw (BeRONJ) when associated with dental implant placement and adjuvant ozone therapy.

CASE PRESENTATION

A 54-year-old female patient with a history of metastatic breast cancer and bevacizumab use presented with a dental infection. Dental extraction followed immediately by dental implant placement was planned after suspension of the bevacizumab treatment. The patient presented with pain, drainage of purulent secretion, and bone exposure 5 weeks post-surgery. Complete healing was achieved at postoperative 7 months.

CONCLUSIONS

The combination of adjuvant ozone therapy and surgical debridement was effective for the treatment of MRONJ; however, the risk of MRONJ may persist after the suspension of bevacizumab for 28 days.

摘要

背景

药物相关性颌骨坏死（MRONJ）的特征是接受抗吸收和/或抗血管生成药物治疗的患者颌骨出现骨坏死。关于贝伐单抗相关性颌骨坏死（BeRONJ）与牙种植体植入及辅助臭氧治疗相关的情况，尚未有科学报告发表。

病例报告

一名54岁有转移性乳腺癌病史且使用过贝伐单抗的女性患者出现牙齿感染。在暂停贝伐单抗治疗后，计划立即进行拔牙并随后植入牙种植体。患者术后5周出现疼痛、脓性分泌物引流及骨暴露。术后7个月实现完全愈合。

结论

辅助臭氧治疗与手术清创相结合对MRONJ治疗有效；然而，在暂停使用贝伐单抗28天后，MRONJ的风险可能仍然存在。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f947/6768921/7a4a45d72d40/40729_2019_188_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f947/6768921/ff5e28204bbe/40729_2019_188_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f947/6768921/5f40bad9cc7c/40729_2019_188_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f947/6768921/8683086ee34e/40729_2019_188_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f947/6768921/fe4e7355a43e/40729_2019_188_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f947/6768921/2c221e6d02c2/40729_2019_188_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f947/6768921/06e3638414e2/40729_2019_188_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f947/6768921/7a4a45d72d40/40729_2019_188_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f947/6768921/ff5e28204bbe/40729_2019_188_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f947/6768921/5f40bad9cc7c/40729_2019_188_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f947/6768921/8683086ee34e/40729_2019_188_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f947/6768921/fe4e7355a43e/40729_2019_188_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f947/6768921/2c221e6d02c2/40729_2019_188_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f947/6768921/06e3638414e2/40729_2019_188_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f947/6768921/7a4a45d72d40/40729_2019_188_Fig7_HTML.jpg

相似文献

1
A rare case of bevacizumab-related osteonecrosis of the jaw associated with dental implants.1例罕见的与牙科种植体相关的贝伐单抗相关性颌骨坏死病例。
Int J Implant Dent. 2019 Oct 1;5(1):34. doi: 10.1186/s40729-019-0188-0.
2
Medication-related osteonecrosis of the jaw: risk factors in patients under biphosphonate versus patients under antiresorptive-antiangiogenic drugs.药物相关性颌骨坏死：双膦酸盐治疗患者与抗吸收-抗血管生成药物治疗患者的风险因素
Minerva Stomatol. 2017 Aug;66(4):135-140. doi: 10.23736/S0026-4970.17.04056-0. Epub 2017 May 10.
3
Medication-Related Osteonecrosis of the Jaw Around Dental Implants: Implant Surgery-Triggered or Implant Presence-Triggered Osteonecrosis?牙种植体周围药物相关性颌骨坏死：种植手术引发的还是种植体存在引发的骨坏死？
J Craniofac Surg. 2016 May;27(3):697-701. doi: 10.1097/SCS.0000000000002564.
4
Bevacizumab-Associated Implant Presence-Triggered Osteonecrosis: A Case Report and Literature Review.贝伐珠单抗相关性假体在位触发的骨坏死：病例报告及文献复习。
J Oral Implantol. 2022 Aug 1;48(4):325-331. doi: 10.1563/aaid-joi-D-21-00155.
5
Medication-related osteonecrosis of the jaw: An update on the memorial sloan kettering cancer center experience and the role of premedication dental evaluation in prevention.药物相关性颌骨坏死：纪念斯隆凯特琳癌症中心经验及预防中预防性牙科评估作用的最新进展
Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 May;125(5):440-445. doi: 10.1016/j.oooo.2018.02.003. Epub 2018 Feb 14.
6
Delayed Diagnosis of Osteonecrosis of the Jaw (ONJ) Associated with Bevacizumab Therapy in Colorectal Cancer Patients: Report of Two Cases.结直肠癌患者中与贝伐单抗治疗相关的颌骨骨坏死延迟诊断：两例报告
Dent J (Basel). 2016 Oct 29;4(4):39. doi: 10.3390/dj4040039.
7
Peri-implant medication-related osteonecrosis of the jaw mimicking endodontic disease in a cancer patient: A case report.癌症患者中类似牙髓病的种植体周围药物相关性颌骨坏死：一例报告
Aust Endod J. 2024 Dec;50(3):709-717. doi: 10.1111/aej.12893. Epub 2024 Oct 12.
8
[Position paper on medication-related osteonecrosis of the jaw (MRONJ)].[关于药物性颌骨坏死（MRONJ）的立场文件]
Wien Med Wochenschr. 2016 Feb;166(1-2):68-74. doi: 10.1007/s10354-016-0437-2.
9
Denosumab-related osteonecrosis of the jaw following non-surgical periodontal therapy: A case report.接受非手术牙周治疗后发生的地舒单抗相关性颌骨坏死：病例报告。
J Clin Periodontol. 2018 May;45(5):570-577. doi: 10.1111/jcpe.12882. Epub 2018 Apr 16.
10
Osteonecrosis of the jaw associated with ziv-aflibercept.与阿柏西普相关的颌骨骨坏死
J Gastrointest Oncol. 2016 Dec;7(6):E81-E87. doi: 10.21037/jgo.2016.05.07.

引用本文的文献

1
Identified Medications Causing Medication-Related Osteonecrosis of the Jaw: A Literature Review.已确定的导致药物相关性颌骨坏死的药物：文献综述
Cureus. 2025 Jun 24;17(6):e86645. doi: 10.7759/cureus.86645. eCollection 2025 Jun.
2
Navigating Stomatologic Complications Secondary to Antineoplastic Agents-A Comprehensive Review.抗肿瘤药物继发口腔并发症的处理——综述
Cancers (Basel). 2025 Mar 21;17(7):1061. doi: 10.3390/cancers17071061.
3
Exploring the Impact of Novel Anti-Cancer Therapies on Jaw Osteonecrosis and Other Bones: A Comprehensive Review.

本文引用的文献

1
Medication-Related Osteonecrosis of the Jaw: MASCC/ISOO/ASCO Clinical Practice Guideline.药物相关性颌骨坏死：MASCC/ISOO/ASCO 临床实践指南。
J Clin Oncol. 2019 Sep 1;37(25):2270-2290. doi: 10.1200/JCO.19.01186. Epub 2019 Jul 22.
2
The influence of Cisplatin-based chemotherapy on the osseointegration of dental implants: An in vivo mechanical and histometrical study.顺铂化疗对牙种植体骨整合的影响：体内机械和组织学研究。
Clin Oral Implants Res. 2019 Jul;30(7):603-616. doi: 10.1111/clr.13445. Epub 2019 May 11.
3
Oral mucosal changes induced by anticancer targeted therapies and immune checkpoint inhibitors.
探索新型抗癌疗法对颌骨坏死及其他骨骼的影响：一项综述
J Clin Med. 2024 Mar 25;13(7):1889. doi: 10.3390/jcm13071889.
4
Angiogenesis Inhibitor Drug-induced Benign Migratory Glossitis in a Patient of Juvenile-onset Recurrent Respiratory Papillomatosis under Maintenance Therapy.血管生成抑制剂药物诱发的青少年复发性呼吸道乳头状瘤病维持治疗患者的良性游走性舌炎
Int J Clin Pediatr Dent. 2024 Jan;17(1):92-96. doi: 10.5005/jp-journals-10005-2739.
5
Ozone infiltration as an adjunctive treatment to piezoelectric surgery in the management of medication-related osteonecrosis of the jaws: case series of 29 patients.臭氧渗透作为一种辅助治疗方法，联合使用压电手术治疗药物相关性颌骨骨坏死：29 例病例系列。
Oral Maxillofac Surg. 2024 Sep;28(3):1197-1207. doi: 10.1007/s10006-024-01246-x. Epub 2024 Mar 25.
6
Ozone therapy effect in medication-related osteonecrosis of the jaw as prevention or treatment: microtomographic, confocal laser microscopy and histomorphometric analysis.臭氧疗法在药物相关性颌骨坏死预防或治疗中的作用：显微断层扫描、共聚焦激光显微镜及组织形态计量学分析
Clin Oral Investig. 2024 Feb 16;28(2):151. doi: 10.1007/s00784-024-05547-z.
7
Novel Cell Therapy Using Mesenchymal Stromal Cell Sheets for Medication-Related Osteonecrosis of the Jaw.使用间充质基质细胞片治疗药物相关性颌骨坏死的新型细胞疗法
Front Bioeng Biotechnol. 2022 May 12;10:902349. doi: 10.3389/fbioe.2022.902349. eCollection 2022.
抗癌靶向治疗和免疫检查点抑制剂引起的口腔黏膜变化
Support Care Cancer. 2017 May;25(5):1713-1739. doi: 10.1007/s00520-017-3629-4. Epub 2017 Feb 22.
4
Antiresorptive agent-related osteonecrosis of the jaw: Position Paper 2017 of the Japanese Allied Committee on Osteonecrosis of the Jaw.抗吸收剂相关颌骨坏死：日本颌骨坏死联合委员会2017年立场文件
J Bone Miner Metab. 2017 Jan;35(1):6-19. doi: 10.1007/s00774-016-0810-7. Epub 2016 Dec 29.
5
Occurrence and risk indicators of medication-related osteonecrosis of the jaw after dental extraction: a systematic review and meta-analysis.拔牙后与药物相关的颌骨坏死的发生和风险指标：系统评价和荟萃分析。
J Clin Periodontol. 2015 Oct;42(10):922-32. doi: 10.1111/jcpe.12455. Epub 2015 Nov 3.
6
What is the impact of bisphosphonate therapy upon dental implant survival? A systematic review and meta-analysis.双膦酸盐治疗对牙种植体存活有何影响？一项系统评价和荟萃分析。
Clin Oral Implants Res. 2016 Feb;27(2):e38-46. doi: 10.1111/clr.12526. Epub 2014 Nov 19.
7
American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update.美国口腔颌面外科医师协会关于药物相关性颌骨坏死的立场文件——2014年更新版
J Oral Maxillofac Surg. 2014 Oct;72(10):1938-56. doi: 10.1016/j.joms.2014.04.031. Epub 2014 May 5.
8
Molecularly targeted drugs for the treatment of cancer: oral complications and pathophysiology.用于治疗癌症的分子靶向药物：口腔并发症与病理生理学
Hippokratia. 2012 Jul;16(3):196-9.
9
Immediate placement of implants into infected sites: a systematic review.将种植体即刻植入感染部位：一项系统评价
Clin Implant Dent Relat Res. 2015 Jan;17 Suppl 1:e1-e16. doi: 10.1111/cid.12098. Epub 2013 Jul 2.
10
Implant treatment choice after extraction of a vertically fractured tooth. A proposal for a clinical classification of bony defects based on a systematic review of literature.垂直骨折牙拔除后的种植治疗选择。基于文献系统评价的骨缺损临床分类建议。
Clin Oral Implants Res. 2014 Aug;25(8):946-56. doi: 10.1111/clr.12164. Epub 2013 Apr 8.