Roychoudhury Shubhadeep, Das Anandan, Panner Selvam Manesh Kumar, Chakraborty Saptaparna, Slama Petr, Sikka Suresh C, Kesari Kavindra Kumar
Department of Life Science and Bioinformatics, Assam University, Silchar, India.
Department of Urology, Tulane University School of Medicine, New Orleans, LA, United States.
Front Cell Dev Biol. 2022 May 12;10:877079. doi: 10.3389/fcell.2022.877079. eCollection 2022.
Radiotherapy, a popular cancer management procedure, negatively impacts reproductive health particularly by reducing the fertility potential. The purpose of this study was to analyze the research trend in radiotherapy associated with male infertility over the past 20 years (2000-May 2021). SCOPUS database was used to retrieve relevant scientometric data (publication per year, affiliation, journals, countries, type of document and area of research) for different subgenres of radiotherapy and male infertility. A total of 275 articles were published related to radiotherapy and male infertility, with the United States being the most dominant country in research output in this field. Radiotherapy and male infertility research have shown positive growth over the last two decades. In-depth analysis revealed that publications (n) related to radiotherapy and male infertility research mainly focused its impact on semen parameters (n = 155) and fertility preservation techniques (n = 169). Our scientometric results highlight a limited research focus on the field of radiotherapy and its impact on male reproductive hormones. Furthermore, a significant lack of research was noticed in the area of omics and male reproductive organs linked to radiotherapy. Substantial research is warranted to further decipher the effect of radiotherapy, at molecular level, leading to male infertility.
放射治疗是一种常见的癌症治疗方法，对生殖健康有负面影响，尤其是会降低生育潜力。本研究的目的是分析过去20年（2000年至2021年5月）与男性不育相关的放射治疗研究趋势。使用SCOPUS数据库检索放射治疗和男性不育不同子领域的相关科学计量数据（每年的出版物、机构、期刊、国家、文献类型和研究领域）。共发表了275篇与放射治疗和男性不育相关的文章，美国是该领域研究产出最多的国家。在过去二十年中，放射治疗和男性不育研究呈积极增长态势。深入分析表明，与放射治疗和男性不育研究相关的出版物（n）主要集中在其对精液参数（n = 155）和生育力保存技术（n = 169）的影响上。我们的科学计量结果突出了对放射治疗领域及其对男性生殖激素影响的研究重点有限。此外，在与放射治疗相关的组学和男性生殖器官领域，研究明显不足。有必要进行大量研究，以进一步从分子水平解读放射治疗导致男性不育的作用。
