周细胞对糖尿病伤口愈合的治疗作用
Therapeutic Effect of Pericytes for Diabetic Wound Healing.
作者信息
Kim Kyeong Mi, An Hyun-Ju, Kim Sang-Hoon, Kim JuHee, Sim Changgon, Lee Jaemin, Park Sin Hyung, Lee Hyun Il, Jang Inseok, Lee Soonchul
机构信息
Department of Laboratory Medicine, CHA Ilsan Medical Center, CHA University School of Medicine, Goyang-si, South Korea.
Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam-si, South Korea.
出版信息
Front Cardiovasc Med. 2022 May 13;9:868600. doi: 10.3389/fcvm.2022.868600. eCollection 2022.
OBJECTIVE
Numerous attempts have been made to devise treatments for ischemic foot ulcer (IFU), which is one of the most severe and fatal consequences of diabetes mellitus (DM). Pericytes, which are perivascular multipotent cells, are of interest as a treatment option for IFU because they play a critical role in forming and repairing various tissues. In this study, we want to clarify the angiogenic potential of pericytes in DM-induced wounds.
METHODS
We evaluated pericyte stimulation capability for tube formation, angiogenesis, and wound healing (cell migration) in human umbilical vein endothelial cells (HUVECs) with and models of high glucose conditions.
RESULTS
When HUVECs were co-cultured with pericytes, their tube-forming capacity and cell migration were enhanced. Our diabetic mouse model showed that pericytes promote wound healing increased vascularization.
CONCLUSION
The findings of this study indicate that pericytes may enhance wound healing in high glucose conditions, consequently making pericyte transplantation suitable for treating IFUs.
目的
缺血性足部溃疡（IFU）是糖尿病（DM）最严重且致命的后果之一，人们已多次尝试设计针对它的治疗方法。周细胞是血管周围的多能细胞，作为IFU的一种治疗选择受到关注，因为它们在各种组织的形成和修复中起关键作用。在本研究中，我们想要阐明周细胞在糖尿病诱导伤口中的血管生成潜力。
方法
我们用高糖条件的和模型评估了周细胞对人脐静脉内皮细胞（HUVECs）的管形成、血管生成和伤口愈合（细胞迁移）的刺激能力。
结果
当HUVECs与周细胞共培养时，它们的管形成能力和细胞迁移增强。我们的糖尿病小鼠模型表明周细胞促进伤口愈合并增加血管化。
结论
本研究结果表明周细胞可能在高糖条件下增强伤口愈合，因此使周细胞移植适合治疗IFU。
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