Institute of Food Safety and Health, College of Public Health, National Taiwan University, Taipei, Taiwan.
Food and Drug Administration, Ministry of Health and Welfare, Executive Yuan, Taipei, Taiwan.
J Food Drug Anal. 2022 Mar 15;30(1):11-25. doi: 10.38212/2224-6614.3397.
Perfluoroalkyl substances (PFASs), as coating materials, possess oil-resistant and waterproof properties. However, their persistency and toxicity have caused concerns. This study developed a method for determining five types of 20 PFASs with ultra-performance liquid chromatography/tandem mass spectrometry, and measured seven categories of 32 commercial samples of oil-resistant food packaging in Taiwan. The assay was validated according to the specification of Taiwan Food and Drug Administration (TFDA). Samples of 100 cm were cut into pieces and were ultra-sonicated in 20-mL methanol at 50 °C for 45 minutes. The extracts were concentrated to 1 mL for instrumental analysis. Most matrix effect factors and extraction efficiencies of the analytes were 50%-80% and 52%-99%, respectively. Most limits of detection and limits of quantification were between 0.07-11.3 ng/dm and 0.17-18.3 ng/dm, respectively. Most recoveries ranged from 70% to 117% at three tested levels, and the precisions (%RSD) were lower than 19%. Microwave popcorn paper contained more types and higher levels of PFASs than other packaging, with perfluoroalkyl acids at 8.3-1960 ng/dm and fluorotelomer alcohols (FTOHs) at 9.7-7188 ng/dm. High concentrations of FTOHs were also observed in one oil-proof paper bag at 454-2595 ng/dm and in one French fries paper bag at 22.4-167 ng/dm.
全氟烷基物质（PFASs）作为涂层材料，具有耐油和防水性能。然而，它们的持久性和毒性引起了人们的关注。本研究开发了一种使用超高效液相色谱/串联质谱法测定 5 种 20 种 PFASs 的方法，并测定了台湾 32 种耐油食品包装的商业样品。该测定方法根据台湾食品药品监督管理局（TFDA）的规范进行了验证。将 100cm 的样品切成小块，在 50°C 下用 20mL 甲醇超声处理 45 分钟。将提取物浓缩至 1mL 进行仪器分析。大多数分析物的基质效应因子和提取效率分别为 50%-80%和 52%-99%。大多数检出限和定量限在 0.07-11.3ng/dm 和 0.17-18.3ng/dm 之间。大多数回收率在三个测试水平下介于 70%-117%之间，精密度（%RSD）低于 19%。微波爆米花纸比其他包装含有更多种类和更高水平的 PFASs，全氟烷基酸含量为 8.3-1960ng/dm，氟端基醇（FTOHs）含量为 9.7-7188ng/dm。在一个防油纸袋中也观察到 FTOHs 的浓度很高，为 454-2595ng/dm，在一个炸薯条纸袋中为 22.4-167ng/dm。
