Mass Spectrometry and Dioxin Analysis Laboratory, INRASTES, NCSR "Demokritos", 15310, Athens, Greece.
Mass Spectrometry and Dioxin Analysis Laboratory, INRASTES, NCSR "Demokritos", 15310, Athens, Greece.
Environ Res. 2019 Oct;177:108617. doi: 10.1016/j.envres.2019.108617. Epub 2019 Jul 31.
Food and drinking water intake are the major routes of exposure to perfluoroalkyl substances (PFASs) for humans. In this study an initial oral exposure assessment of the non-occupationally exposed general Greek population to PFASs is presented. Levels of PFOA and PFOS determined in the present study in 128 food items from the Greek market and previously published analytical results of 43 water samples and 76 egg samples from Greece were combined with food availability data of the DAFNE-ANEMOS database for the calculation of oral intake of PFASs. Fish form the food group with the highest concentration in both PFOA and PFOS. For the general Greek population the estimated average daily intake in PFOA and PFOS when applying the lowerbound mean concentrations in food and drinking water samples is 0.49 and 0.91 ng kg body weight (b.w.) respectively. The main contributor to oral PFAS intake is fish. A pharmacokinetic model is applied to estimate total intake from blood serum levels reported previously and the predicted values are in agreement with lowerbound estimated values. Weekly intake estimated values are below the tolerable weekly intake recently proposed by EFSA.
食物和饮水是人类接触全氟烷基物质 (PFASs) 的主要途径。本研究对非职业暴露的普通希腊人群进行了 PFASs 的初步口服暴露评估。本研究在 128 种希腊市场食品中测定了 PFOA 和 PFOS 的水平，并结合了 DAFNE-ANEMOS 数据库中 43 个水样和 76 个蛋样的先前发表的分析结果，用于计算 PFASs 的口服摄入量。鱼类是 PFOA 和 PFOS 浓度最高的食物组。对于普通希腊人群，当应用食物和饮用水样本中浓度的低值时，估计的 PFOA 和 PFOS 的平均日摄入量分别为 0.49 和 0.91ng/kg 体重(b.w.)。鱼类是口服 PFAS 摄入量的主要来源。应用药代动力学模型估算了以前报告的血清水平的总摄入量，预测值与低值估计值一致。每周的摄入量估计值低于 EFSA 最近提出的可耐受每周摄入量。
