Department of Orthopedics, Suzhou Kowloon Hospital, Shanghai Jiaotong University, School of Medicine, Suzhou, Jiangsu, China.
Eur Rev Med Pharmacol Sci. 2022 May;26(10):3642-3647. doi: 10.26355/eurrev_202205_28859.
The study was undertaken to determine the clinical effectiveness of percutaneous kyphoplasty (PKP) with unilateral balloon infusion of low dose of bone cement for treatment of osteoporotic vertebral compression fractures (OVCFs) in the elderly.
A retrospective study was carried out. A total of 36 patients with OVCFs treated by PKP from August 2019 and August 2020 were included. Patients were divided into two groups according to the amount of bone cement infused into the vertebral body. The amount of cement in conventional-dose group was 3.5-6.0 mL and the amount of cement in small-dose group was 1.8-3.0 mL. Pain relief before and after the operation were evaluated, and the leakage of bone cement in the two groups was also observed.
Two groups of patients have obtained a good clinical efficacy. Pain has significant differences before and after the operation (p < 0.05). More importantly, compared with conventional-dose group, small-dose group has lower bone cement leakage rate (p < 0.05).
PKP with small-dose bone cement infusion can obtain the same clinical effects of conventional-dose, but the incidence of bone cement leakage is lower and safe.
本研究旨在探讨单侧球囊低压灌注小剂量骨水泥经皮椎体后凸成形术（PKP）治疗老年骨质疏松性椎体压缩性骨折（OVCF）的临床疗效。
回顾性研究。纳入 2019 年 8 月至 2020 年 8 月采用 PKP 治疗的 36 例 OVCF 患者。根据向椎体注入骨水泥的量将患者分为两组，常规剂量组骨水泥用量为 3.5-6.0 mL，小剂量组骨水泥用量为 1.8-3.0 mL。评估手术前后的疼痛缓解情况，并观察两组骨水泥渗漏情况。
两组患者均获得了良好的临床疗效。术后疼痛与术前相比有显著差异（p<0.05）。更重要的是，与常规剂量组相比，小剂量组的骨水泥渗漏发生率更低（p<0.05）。
PKP 采用小剂量骨水泥灌注可获得与常规剂量相同的临床效果，但骨水泥渗漏发生率较低，安全性更高。
