Clark Emma, Faruque Saurab, Mutebi Cedric, Nagirimadugu Newton V, Kim Alyssa, Mahendran Malavika, Sullo Elaine, Morey Rajendra, Turner Robert W
University of California, Berkeley, USA.
School of Medicine, University of Pittsburgh, Pittsburgh, USA.
J Neurol. 2022 Sep;269(9):4635-4645. doi: 10.1007/s00415-022-11186-9. Epub 2022 Jun 1.
The objective of this systematic review is to synthesize the relevant literature published after 2016 to ascertain the current landscape of science that relates mild traumatic brain injury (mTBI) to the onset of Alzheimer's disease and related dementias (ADRD) and identify areas of need for future research. We conducted database searches and retrieved articles that were published after 2016 that utilized cognitive assessments to understand the relationship between mTBI and ADRD. We identified eight relevant articles in the review process, four of which presented a significant relationship between mTBI and disease or cognitive impairment outcomes. The studies included in this systematic review underscore the need for future research investigating a possible causal relationship between mTBI and ADRDs given the high prevalence of mTBI among brain injury patients and the lack of literature specifically addressing this issue. Future research should standardize the definitions of mTBI, AD, and ADRDs to create reliable and reproducible results that more comprehensively capture the nuances of this relationship.
本系统评价的目的是综合2016年后发表的相关文献，以确定将轻度创伤性脑损伤（mTBI）与阿尔茨海默病及相关痴呆症（ADRD）发病相关联的当前科学状况，并确定未来研究的需求领域。我们进行了数据库检索，并检索了2016年后发表的利用认知评估来理解mTBI与ADRD之间关系的文章。我们在综述过程中确定了8篇相关文章，其中4篇表明mTBI与疾病或认知障碍结果之间存在显著关系。鉴于mTBI在脑损伤患者中的高患病率以及缺乏专门针对这一问题的文献，本系统评价中纳入的研究强调了未来研究调查mTBI与ADRD之间可能因果关系的必要性。未来的研究应规范mTBI、AD和ADRD的定义，以产生可靠且可重复的结果，从而更全面地捕捉这种关系的细微差别。
