Laczi F, Janáky T, Iványi T, Julesz J, László F A
Acta Endocrinol (Copenh). 1987 Mar;114(3):389-95. doi: 10.1530/acta.0.1140389.
The osmoregulation of arginine-8-vasopressin (AVP) was investigated in 14 patients with primary hypothyroidism and in 6 with Addison's disease. Plasma AVP was measured by radioimmunoassay. Patients with primary hypothyroidism were classified into subgroups with elevated (6.81 +/- 1.12 pmol/l) or normal (3.92 +/- 0.96 pmol/l) basal levels of plasma AVP. Following the infusion of 2.5% saline, a positive correlation was established between plasma AVP and plasma osmolality. A decreased osmotic threshold was found in hypothyroid patients with augmented basal AVP levels (pAVP = 0.37 (pOs-265), r = 0.71, P less than 0.01) as compared with that in hypothyroid patients with a normal AVP level (pAVP = 0.42 (pOs-280), r = 0.93, P less than 0.001). A relationship was demonstrated between the alteration in the AVP osmoregulation and the severity of the thyroid insufficiency. Patients with Addison's disease exhibited an increased basal level of plasma AVP (9.59 +/- 1.25 pmol/l) and a decreased osmotic threshold (pAVP = 0.42 (pOs-261), r = 0.63, P less than 0.01) contrasted to that of healthy volunteers (pAVP = 0.41 (pOs-280), r = 0.83, P less than 0.001). The osmoregulation disturbance of the AVP secretion may play a major role in the impaired water metabolism in primary hypothyroidism and in Addison's disease.
对14例原发性甲状腺功能减退患者和6例艾迪生病患者的精氨酸 - 8 - 血管加压素（AVP）的渗透调节进行了研究。采用放射免疫分析法测定血浆AVP。原发性甲状腺功能减退患者被分为血浆AVP基础水平升高（6.81±1.12 pmol/l）或正常（3.92±0.96 pmol/l）的亚组。输注2.5%盐水后，血浆AVP与血浆渗透压之间建立了正相关关系。与AVP水平正常的甲状腺功能减退患者相比，基础AVP水平升高的甲状腺功能减退患者的渗透阈值降低（pAVP = 0.37（pOs - 265），r = 0.71，P＜0.01）（pAVP = 0.42（pOs - 280），r = 0.93，P＜0.001）。AVP渗透调节的改变与甲状腺功能不全的严重程度之间存在关联。与健康志愿者相比，艾迪生病患者的血浆AVP基础水平升高（9.59±1.25 pmol/l）且渗透阈值降低（pAVP = 0.42（pOs - 261），r = 0.63，P＜0.01）（pAVP = 0.41（pOs - 280），r = 0.83，P＜0.001）。AVP分泌的渗透调节紊乱可能在原发性甲状腺功能减退和艾迪生病的水代谢受损中起主要作用。
