Spruce B A, Baylis P H, Burd J, Watson M J
Clin Endocrinol (Oxf). 1985 Jan;22(1):37-42. doi: 10.1111/j.1365-2265.1985.tb01062.x.
Osmoregulation of vasopressin secretion was studied in eight healthy women in the follicular and luteal phases of the menstrual cycle. Basal plasma osmolality in the luteal phase was significantly lower than in the follicular period (282.4 +/- 0.6, 285.6 +/- 1.1mmol/kg, respectively, P less than 0.05). Plasma AVP (pAVP) and plasma osmolality (pOsm) were measured during the infusion of 850 mmol/l saline in both phases of the cycle, and linear regression analyses of these data gave the following regression equations (i) follicular, pAVP = 0.43 (pOsm - 284), r = + 0.93, (ii) luteal, pAVP = 0.31 (pOsm - 279), r = + 0.95. Both the slope and abscissal intercept were significantly different (P less than 0.01). Osmotic threshold for thirst sensation in the luteal phase was lower than the follicular (293 +/- 2,297 +/- 1 mmol/kg, P less than 0.005). We conclude that, in the luteal phase, the threshold for AVP release and the gain or sensitivity of the osmostat are reduced together with lowering of the thirst threshold, which account for the lower basal luteal plasma osmolality.
对8名处于月经周期卵泡期和黄体期的健康女性的血管加压素分泌的渗透调节进行了研究。黄体期的基础血浆渗透压显著低于卵泡期（分别为282.4±0.6、285.6±1.1mmol/kg，P<0.05）。在月经周期的两个阶段输注850mmol/l盐水期间测量血浆抗利尿激素（pAVP）和血浆渗透压（pOsm），对这些数据进行线性回归分析得出以下回归方程：（i）卵泡期，pAVP = 0.43（pOsm - 284），r = + 0.93；（ii）黄体期，pAVP = 0.31（pOsm - 279），r = + 0.95。斜率和横坐标截距均有显著差异（P<0.01）。黄体期口渴感觉的渗透阈值低于卵泡期（293±2、297±1mmol/kg，P<0.005）。我们得出结论，在黄体期，抗利尿激素释放阈值和渗透压调节器的增益或敏感性降低，同时口渴阈值降低，这解释了黄体期基础血浆渗透压较低的原因。
