Shenzhen Key Laboratory of Marine Bioresources and Ecology, Brain Disease and Big Data Research Institute, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518055, Guangdong Province, China.
Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, Guangdong Province, China.
Metallomics. 2022 Jul 14;14(7). doi: 10.1093/mtomcs/mfac037.
Metals play a critical role in human health and diseases. In recent years, metallomics has been introduced and extensively applied to investigate the distribution, regulation, function, and crosstalk of metal(loid) ions in various physiological and pathological processes. Based on high-throughput multielemental analytical techniques and bioinformatics methods, it is possible to elucidate the correlation between the metabolism and homeostasis of diverse metals and complex diseases, in particular for cancer. This review aims to provide an overview of recent progress made in the application of metallomics in cancer research. We mainly focuses on the studies about metallomic profiling of different human biological samples for several major types of cancer, which reveal distinct and dynamic patterns of metal ion contents and the potential benefits of using such information in the detection and prognosis of these malignancies. Elevated levels of copper appear to be a significant risk factor for various cancers, and each type of cancer has a unique distribution of metals in biofluids, hair/nails, and tumor-affected tissues. Furthermore, associations between genetic variations in representative metalloprotein genes and cancer susceptibility have also been demonstrated. Overall, metallomics not only offers a better understanding of the relationship between metal dyshomeostasis and the development of cancer but also facilitates the discovery of new diagnostic and prognostic markers for cancer translational medicine.
金属在人类健康和疾病中起着至关重要的作用。近年来，金属组学被引入并广泛应用于研究各种生理和病理过程中金属（类）离子的分布、调控、功能和相互作用。基于高通量多元素分析技术和生物信息学方法，可以阐明多种金属代谢与内稳态与复杂疾病之间的相关性，特别是癌症。本综述旨在概述金属组学在癌症研究中的应用的最新进展。我们主要关注不同人类生物样本在几种主要类型癌症中的金属组学分析研究，这些研究揭示了金属离子含量的不同和动态模式，以及在这些恶性肿瘤的检测和预后中使用这些信息的潜在益处。铜水平升高似乎是各种癌症的一个重要危险因素，每种类型的癌症在生物体液、头发/指甲和受肿瘤影响的组织中都有独特的金属分布。此外，还证明了代表性金属蛋白基因中的遗传变异与癌症易感性之间存在关联。总体而言，金属组学不仅提供了对金属失调与癌症发展之间关系的更好理解，还促进了癌症转化医学中新的诊断和预后标志物的发现。
