Department of Chemistry, Indian Institute of Technology Ropar, SS Bhatnagar Block, Main Campus, Rupnagar, Punjab-140001, India.
Org Biomol Chem. 2022 Jun 22;20(24):4933-4941. doi: 10.1039/d2ob00530a.
A chemoselective and metal/additive-free protocol for the synthesis of propargylic cyclic imine derivatives (3 + 2)-cycloaddition of donor-acceptor cyclopropanes and alkynylnitriles in the presence of BF·OEt has been established. The newly developed methodology provided access to a variety of propargylic cyclic imines in good to excellent yields. In addition, the synthesis of propargylic amines and the corresponding very stable enol derivatives from the title compound is also explored.
建立了一种在 BF·OEt 存在下，通过供体-受体环丙烷和炔基腈的[3+2]-环加成反应，选择性合成炔丙基环状亚胺衍生物的无金属/添加剂方法。新开发的方法可以很好地获得各种炔丙基环状亚胺，收率优良。此外，还探索了从标题化合物合成炔丙基胺和相应的非常稳定的烯醇衍生物。
