镍催化乙烯基环丙烷与亚胺的环加成反应。
Nickel-catalyzed cycloaddition of vinylcyclopropanes to imines.
机构信息
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
出版信息
Org Lett. 2013 Apr 19;15(8):1791-3. doi: 10.1021/ol4005068. Epub 2013 Apr 8.
PMID:23565672
Abstract
Nickel-catalyzed intermolecular [3 + 2] cycloaddition of vinylcyclopropanes to imines has been developed. This transformation generates substituted pyrrolidines in high yields, with good regio- and diastereo- selectivity under mild reaction conditions. A variety of imines can be used in this reaction. An asymmetric variant of the reaction has also been demonstrated.
摘要
镍催化的乙烯基环丙烷与亚胺的分子间[3 + 2]环加成反应已经被开发出来。在温和的反应条件下，该转化以高产率生成取代的吡咯烷，具有良好的区域和立体选择性。该反应可以使用各种亚胺。该反应的不对称变体也已经得到证明。
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