Seo Jiae, Choi Jae-Won, Koh Young-Hag, Seo Ji-Hun
Department of Materials Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Korea.
Department of Biomedical Engineering, Korea University, Seoul 02841, Korea.
ACS Macro Lett. 2020 Mar 17;9(3):389-395. doi: 10.1021/acsmacrolett.9b00996. Epub 2020 Feb 27.
The purpose of this study is to develop mechanically robust soybean oil and polycaprolactone (PC)-based drug-eluting shape memory polymers (SMPs) containing polyrotaxane (PRX) cross-linkers. Essentially, the dynamic PRX cross-linker-containing methacrylate group is introduced to increase the cross-linking density and flexibility of the SMP to overcome its mechanical limitations. It was confirmed that the elongation and cross-linking density of the PRX-incorporated SMP were increased by 2-4 times compared to neat SMP. In addition, those high mechanical properties of the PRX-incorporated SMP could be maintained after the degradation of the PC by the drug-eluting process.
本研究的目的是开发基于机械性能强大的大豆油和聚己内酯（PC）的含聚轮烷（PRX）交联剂的药物洗脱形状记忆聚合物（SMP）。从本质上讲，引入含动态PRX交联剂的甲基丙烯酸酯基团是为了提高SMP的交联密度和柔韧性，以克服其机械性能方面的局限性。结果证实，与纯SMP相比，含PRX的SMP的伸长率和交联密度提高了2至4倍。此外，通过药物洗脱过程使PC降解后，含PRX的SMP的那些高机械性能仍可得以保持。
