Ming Hao, Tian ChenXu, He Nan, Zhao Xin, Luo Feng, Li Zhen, Li Jiehua, Tan Hong, Fu Qiang
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, China.
J Biomater Sci Polym Ed. 2022 Oct;33(14):1811-1827. doi: 10.1080/09205063.2022.2085342. Epub 2022 Jun 8.
Considerable implant materials are prone to cause a severe inflammatory reaction due to poor histocompatibility, which leads to various complications and implant failure. Surface coating modification of these implant materials is one of the most important techniques to settle this problem. However, fabricating a coating with both adequate adhesiveness and excellent biocompatibility remains a challenge. Inspired by the adhesion mechanism of mussels, a series of mussel-inspired polyurethanes (PU-LDAs) were synthysized through a step growth polymerization based on hexamethylene diisocyanate as a hard segment, polytetra-methylene-ether-glycol as a soft segment, lysine-dopamine (LDA) and butanediol as chain extenders with different mole ratios.The coatings of PU-LDAs were applied to various substrates, such as stainless steel, glass and PP using a facile one-step coating process. The introduction of 3,4-dihydroxyphenylalanine (DOPA) groups can greatly improve the adhesion ability of the coatings to the substrates demonstrated by a 180° peel test. The peel strength of the PU-LDA100 coating containing high LDA content was 76.3, 48.5 and 67.5 N/m, which was 106.2%, 246.4% and 192.2% higher than that of the PU-LDA00 coating without LDA on the surface of stainless steel, glass and PP, respectively. Meanwhile, this PU coating has a lower immune inflammatory response which provides a universal method for surface modification of implant materials. Moreover, the DOPA groups in PU-LDAs could combine with the amino and thiol groups on cell membrane surface, leading to the improvement of cell adhesion and growth. Therefore, it has great potential application in the field of biomedical implant materials for the clinic.
相当多的植入材料由于组织相容性差而容易引发严重的炎症反应，这会导致各种并发症和植入失败。对这些植入材料进行表面涂层改性是解决该问题的最重要技术之一。然而，制备具有足够附着力和优异生物相容性的涂层仍然是一个挑战。受贻贝粘附机制的启发，通过基于六亚甲基二异氰酸酯作为硬段、聚四亚甲基醚二醇作为软段、赖氨酸 - 多巴胺（LDA）和丁二醇作为扩链剂，以不同摩尔比进行逐步增长聚合反应，合成了一系列受贻贝启发的聚氨酯（PU - LDA）。采用简便的一步涂层工艺将PU - LDA涂层应用于各种基材，如不锈钢、玻璃和聚丙烯。3,4 - 二羟基苯丙氨酸（DOPA）基团的引入可显著提高涂层对基材的粘附能力，180°剥离试验证明了这一点。含高LDA含量的PU - LDA100涂层在不锈钢、玻璃和聚丙烯表面的剥离强度分别为76.3、48.5和67.5 N/m，分别比表面无LDA的PU - LDA00涂层高106.2%、246.4%和192.2%。同时，这种聚氨酯涂层具有较低的免疫炎症反应，为植入材料的表面改性提供了一种通用方法。此外，PU - LDA中的DOPA基团可与细胞膜表面的氨基和巯基结合，从而改善细胞粘附和生长。因此，它在临床生物医学植入材料领域具有巨大的潜在应用价值。
