Wang Guangzhi, Wang Longgang, Lin Weifeng, Wang Zhen, Zhang Juan, Ji Fangqin, Ma Guanglong, Yuan Zhefan, Chen Shengfu
†Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
‡Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, China.
ACS Appl Mater Interfaces. 2015 Aug 12;7(31):16938-45. doi: 10.1021/acsami.5b05162. Epub 2015 Jul 28.
Polyurethane with zwitterionic side chains (PCB-ester-PU) based on a poly(carboxybetaine) ester analogue is developed for marine coatings and biomedical applications by introducing dihydroxy-terminated PCB-ester(OH)2 with different polymerization as the macrodiol, 4,4'-diphenylmethane diisocyanate (MDI) as the diisocyanate, and 1,4-butanediol (1,4-BD) as the chain extender. Robust coatings are obtained and exhibit long-term excellent resistance to nonspecific protein adsorption, bacterial adhesion, and human umbilical vein endothelial cell (HUVEC) attachment after hydrolysis. Tests of adhesion on different substrates and film hardness indicate that the material possesses far more stable mechanic properties than hydrogel coatings. Moreover, such a resistance can be generated not only by alkaline solution, but also by a physiological buffer (such as phosphate-buffered saline (0.15 M pH 7.4 PBS)) or by steam in an autoclave. Ultimately, its excellent long-term nonfouling property, its healing capability through self-regeneration and superior mechanic properties (such as hardness and elasticity), and its good adhesiveness as a paint on both polar and nonpolar substrates make this material an ideal candidate as a coating for marine and medical devices.
基于聚（羧酸甜菜碱）酯类似物的带有两性离子侧链的聚氨酯（PCB-酯-PU），通过引入不同聚合度的二羟基封端的PCB-酯(OH)₂作为大分子二醇、4,4'-二苯基甲烷二异氰酸酯（MDI）作为二异氰酸酯以及1,4-丁二醇（1,4-BD）作为扩链剂，被开发用于海洋涂料和生物医学应用。制备出了坚固的涂层，该涂层在水解后表现出对非特异性蛋白质吸附、细菌粘附和人脐静脉内皮细胞（HUVEC）附着的长期优异抗性。在不同基材上的附着力测试和薄膜硬度测试表明，该材料具有比水凝胶涂层更稳定的机械性能。此外，这种抗性不仅可以由碱性溶液产生，还可以由生理缓冲液（如磷酸盐缓冲盐水（0.15 M pH 7.4 PBS））或高压灭菌器中的蒸汽产生。最终，其优异的长期防污性能、通过自我再生的愈合能力以及卓越的机械性能（如硬度和弹性），以及作为涂料在极性和非极性基材上的良好附着力，使这种材料成为海洋和医疗设备涂层的理想候选材料。
