Wegg Michaela L, Pollard Danica, Ofri Ron
The Roslin Institute, The University of Edinburgh, Midlothian, UK.
The Rodhams, Wisbech, UK.
Vet Ophthalmol. 2023 Mar;26(2):145-154. doi: 10.1111/vop.13001. Epub 2022 Jun 1.
Electroretinography (ERG) is used prior to cataract removal surgery to assess retinal function. We aimed to replicate and improve upon previous studies by performing a full ECVO protocol and by examining the retina post-surgery in all patients.
One hundred twenty-seven eyes from 67 dogs were included in the study.
A full ECVO protocol electroretinography, which includes extensive rod and cone analysis, was performed on all dogs presenting for cataract surgery.
Our main findings were that amplitudes, but not implicit times of rod responses decreased with advanced cataracts. Amplitudes of the single flash rod and rod flicker responses were significantly lower in eyes with mature cataracts, and the former also decreased in hypermature cataracts. Cone flicker amplitude responses were also significantly lower in eyes with mature and hypermature cataracts. However, mixed single flash rod-cone and cone responses, with the exception of the mixed rod-cone a-wave amplitude in eyes with hypermature cataracts, were unaffected by cataract stage. The b-wave amplitude of the scotopic, mixed rod-cone, and photopic cone responses were affected by age and decreased by an average of 2.9, 7.5, and 1.5 μV/year, retrospectively (p < 0.01).
Lower ERG amplitudes in canine cataract patients may result from aging or the presence of advanced cataracts and may not indicate the presence of retinal disease.
白内障摘除手术前使用视网膜电图（ERG）评估视网膜功能。我们旨在通过执行完整的ECVO方案并检查所有患者术后的视网膜来重复并改进先前的研究。
该研究纳入了67只犬的127只眼睛。
对所有前来接受白内障手术的犬只进行了完整的ECVO方案视网膜电图检查，其中包括广泛的视杆和视锥细胞分析。
我们的主要发现是，随着白内障病情加重，视杆细胞反应的振幅降低，但潜伏期未受影响。成熟白内障患眼的单次闪光视杆细胞和视杆细胞闪烁反应的振幅显著降低，在过熟期白内障患眼中，前者也有所下降。成熟和过熟白内障患眼的视锥细胞闪烁振幅反应也显著降低。然而，除过熟期白内障患眼的混合视杆-视锥细胞a波振幅外，混合单次闪光视杆-视锥细胞和视锥细胞反应不受白内障分期的影响。暗视、混合视杆-视锥细胞和明视视锥细胞反应的b波振幅受年龄影响，回顾性分析显示平均每年分别下降2.9、7.5和1.5 μV（p < 0.01）。
犬白内障患者较低的ERG振幅可能是由于衰老或存在晚期白内障，不一定表明存在视网膜疾病。
