Grozdanic Sinisa D, Kecova Helga, Lazic Tatjana
Animal Eye Consultants of Iowa, 25 E Weston Drive, North Liberty, IA 52317, USA.
Vet Ophthalmol. 2013 Sep;16(5):329-40. doi: 10.1111/vop.12003. Epub 2012 Dec 10.
To develop fast and reliable testing routines for diagnosing retina and optic nerve diseases in canine cataract patients based on chromatic properties of the pupillary light reflex response.
Seventy-seven canine patients with a history of cataract and decreased vision (43 patients with cataracts and no evidence of retina or optic nerve disease, 21 patients with cataracts and retinal degeneration [RD], 13 patients with cataracts and retinal detachment [RDT]), 11 canine patients with optic neuritis (ON) and 23 healthy dogs were examined using chromatic pupillary light reflex (cPLR) analysis with red and blue light and electroretinography.
Electroretinography analysis showed statistically significant deficits in a- and b-wave amplitudes in dogs with cataracts and RD, or cataracts and RDT, when compared to dogs with cataracts without evidence of retinal abnormalities. Evaluation of b-wave amplitudes showed that presence of 78.5-μV (or lower) amplitudes had high sensitivity of 100% (95% CI: 87.2-100%) and high specificity of 96.7% (95% CI: 88.4-100%) in RD and RDT. Evaluation of cPLR responses using red light showed that presence of the pupil end constriction diameter of 5.5 mm (or higher) had moderately high sensitivity of 76.5% (95% CI: 50.1-93.2%) and high specificity of 100% (95% CI: 91.2-100%) in detecting RD and RDT. Optic neuritis patients had absent cPLR responses, regardless of the visual status.
Chromatic evaluation of the pupillary light reflex is a rapid and accurate test for diagnosing retina and optic nerve diseases in canine patients.
基于瞳孔光反射反应的色度特性，开发快速可靠的检测程序，用于诊断犬白内障患者的视网膜和视神经疾病。
对77只患有白内障且视力下降的犬患者（43只患有白内障且无视网膜或视神经疾病证据的患者，21只患有白内障且视网膜变性[RD]的患者，13只患有白内障且视网膜脱离[RDT]的患者）、11只患有视神经炎（ON）的犬患者和23只健康犬，使用红光和蓝光的彩色瞳孔光反射（cPLR）分析以及视网膜电图进行检查。
视网膜电图分析显示，与无视网膜异常证据的白内障犬相比，患有白内障和RD或白内障和RDT的犬在a波和b波振幅上存在统计学显著差异。对b波振幅的评估表明，78.5 μV（或更低）振幅的存在对RD和RDT具有100%的高敏感性（95%可信区间：87.2 - 100%）和96.7%的高特异性（95%可信区间：88.4 - 100%）。使用红光对cPLR反应的评估表明，瞳孔最终收缩直径为5.5 mm（或更高）的存在对检测RD和RDT具有76.5%的中度高敏感性（95%可信区间：50.1 - 93.2%）和100%的高特异性（95%可信区间：91.2 - 100%）。视神经炎患者无论视力状况如何，cPLR反应均缺失。
瞳孔光反射的色度评估是诊断犬患者视网膜和视神经疾病的快速准确测试。
