体外饥饿大鼠胰岛胰岛素分泌的再激活
Insulin secretion reactivation of pancreatic islets from starved rats in vitro.
作者信息
Hahn H J, Gottschling H D
出版信息
Acta Biol Med Ger. 1977;36(10):1423-7.
PMID:356495
Abstract
Starvation of Wistar rats induced a shift of glucose threshold for insulin secretion of isolated islets above 5 mM, which can be restored by pretreatment of the tissue with glucose, mannose, glyceraldehyde, an theophylline, but not with acetylcholine or lactate. The improved insulin secretion is not connected with an enhanced glucose utilization.
摘要
对Wistar大鼠进行饥饿处理，会导致分离胰岛胰岛素分泌的葡萄糖阈值升高至5 mM以上，而通过用葡萄糖、甘露糖、甘油醛和茶碱对组织进行预处理可使其恢复，但用乙酰胆碱或乳酸预处理则无法恢复。胰岛素分泌改善与葡萄糖利用增强无关。
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