饥饿对[14C]腺苷氧化及离体小鼠胰岛腺苷诱导的胰岛素释放的相反作用。
Opposite effects of starvation on oxidation of [14C]adenosine and adenosine-induced insulin release by isolated mouse pancreatic islets.
作者信息
Andersson A
出版信息
Biochem J. 1978 Nov 15;176(2):619-21. doi: 10.1042/bj1760619.
Abstract
To test further the hypothesis that ribonucleosides stimulate insulin secretion and biosynthesis by producing metabolic signals, the effects of starvation on adenosine-stimulated insulin production and the oxidation of adenosine by isolated mouse pancreatic islets were examined. No direct correlation was found between the metabolic flux and insulin secretion, since the starvation-induced impairment of the adenosine-stimulated insulin secretion was accompanied by an increased rate of adenosine oxidation. Adenosine-stimulated insulin biosynthesis was, however, unaffected by starvation.
摘要
为了进一步验证核糖核苷通过产生代谢信号刺激胰岛素分泌和生物合成这一假说，研究了饥饿对腺苷刺激的胰岛素生成的影响以及分离的小鼠胰岛对腺苷的氧化作用。由于饥饿引起的腺苷刺激的胰岛素分泌受损伴随着腺苷氧化速率的增加，因此未发现代谢通量与胰岛素分泌之间存在直接相关性。然而，腺苷刺激的胰岛素生物合成不受饥饿的影响。
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